BINDING OF THE GLUCOCORTICOID AND ESTROGEN-RECEPTORS TO THE HUMAN H-RAS ONCOGENE SEQUENCES

  • Authors:
    • G ZACHOS
    • V ZOUMPOURLIS
    • CE SEKERIS
    • DA SPANDIDOS
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.595
  • Pages: 595-600
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Abstract

There is evidence that hormone regulation of cellular oncogenes plays an essential role in human cancer. The c-H-ras gene is implicated through both mutation and abnormal gene expression in many types of human cancer. Computer scanning of this gene has revealed two putative hormone response motifs: A possible Glucocorticoid Response Element (GRE) at position 1261 of the first intron of the H-ras1 gene and a putative Estrogen Response Element (ERE), at position 3007 of the fourth intron of the gene. In DNA binding assays, using the HeLa and LATK-cell lines, we showed specific binding of the corresponding receptors at both putative H-ras glucocorticoid and estrogen response sequences, suggesting that hormones could be contributing to H-ras transcriptional regulation through interaction with their corresponding Hormone Response Elements (HREs).

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ZACHOS G, ZOUMPOURLIS V, SEKERIS C and SPANDIDOS D: BINDING OF THE GLUCOCORTICOID AND ESTROGEN-RECEPTORS TO THE HUMAN H-RAS ONCOGENE SEQUENCES. Int J Oncol 6: 595-600, 1995.
APA
ZACHOS, G., ZOUMPOURLIS, V., SEKERIS, C., & SPANDIDOS, D. (1995). BINDING OF THE GLUCOCORTICOID AND ESTROGEN-RECEPTORS TO THE HUMAN H-RAS ONCOGENE SEQUENCES. International Journal of Oncology, 6, 595-600. https://doi.org/10.3892/ijo.6.3.595
MLA
ZACHOS, G., ZOUMPOURLIS, V., SEKERIS, C., SPANDIDOS, D."BINDING OF THE GLUCOCORTICOID AND ESTROGEN-RECEPTORS TO THE HUMAN H-RAS ONCOGENE SEQUENCES". International Journal of Oncology 6.3 (1995): 595-600.
Chicago
ZACHOS, G., ZOUMPOURLIS, V., SEKERIS, C., SPANDIDOS, D."BINDING OF THE GLUCOCORTICOID AND ESTROGEN-RECEPTORS TO THE HUMAN H-RAS ONCOGENE SEQUENCES". International Journal of Oncology 6, no. 3 (1995): 595-600. https://doi.org/10.3892/ijo.6.3.595