OF/LB COLLAGEN PROMOTES CHEMOINVASION OF BREAST-CANCER CELLS AND DIRECTS EPITHELIAL-CELL MIGRATION INTO GRANULATION-TISSUE OF EXPERIMENTAL DERMAL WOUNDS

PUCCIMINAFRA,I; LUPARELLO,C; AQUINO,A; BASIRICO,L; MINAFRA,S; FRANC,S; YAKOVLEV,L; SHOSHAN,S

doi:10.3892/ijo.6.5.1015

OF/LB COLLAGEN PROMOTES CHEMOINVASION OF BREAST-CANCER CELLS AND DIRECTS EPITHELIAL-CELL MIGRATION INTO GRANULATION-TISSUE OF EXPERIMENTAL DERMAL WOUNDS

Authors:
- I PUCCIMINAFRA
- C LUPARELLO
- A AQUINO
- L BASIRICO
- S MINAFRA
- S FRANC
- L YAKOVLEV
- S SHOSHAN
View Affiliations

Affiliations: UNIV PALERMO,CTR ONCOBIOL SPERIMENTALE,I-91028 PALERMO,ITALY. UNIV PALERMO,IST ISTOL & EMBRIOL,I-91028 PALERMO,ITALY. INST BIOL & CHIM PROT,CNRS,UPR 412,LYON 07,FRANCE. HEBREW UNIV JERUSALEM,HADASSAH MED SCH,CONNECT TISSUE RES LABS,JERUSALEM,ISRAEL.
Published online on: May 1, 1995 https://doi.org/10.3892/ijo.6.5.1015
Pages: 1015-1020

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Abstract

OF/LB collagen is a recently described once-fetal form of collagen, with laminin-binding properties, composed of three alpha(1)(I)-sized chains, one of which displaying an unusually acidic pI. This collagen appears able to direct the migration of breast cancer cells through Matrigel, and of injury-activated epithelial cells into the underlying granulation stromal tissue. The effect exerted by OF/LB collagen in vitro appears preferentially linked to its acidic chain. The data reported strongly support the hypothesis that the presence and accumulation of OF/LB collagen in cancer may play a fundamental role in the invasive growth.