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RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU

  • Authors:
    • A MATIN
    • YM XIE
    • MC KAO
    • MC HUNG

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  • Published online on: May 1, 1995     https://doi.org/10.3892/ijo.6.5.1087
  • Pages: 1087-1092
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Abstract

The rat neu oncogene encodes a dominant transforming oncogene. The mouse wild-type p53 suppresses the transforming activity of the neu oncogene while different p53 mutants demonstrate varying ability to repress neu-induced transformation. Suppression of neu-transforming activity is due to inhibition of transcription. Deletion analysis of the rat neu promoter shows that p53 represses the basal promoter activity of neu. Therefore, rodent p53 suppresses the transforming potential of neu by inhibiting transcription from the basal promoter of neu.

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May 1995
Volume 6 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
MATIN A, XIE Y, KAO M and HUNG M: RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU. Int J Oncol 6: 1087-1092, 1995
APA
MATIN, A., XIE, Y., KAO, M., & HUNG, M. (1995). RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU. International Journal of Oncology, 6, 1087-1092. https://doi.org/10.3892/ijo.6.5.1087
MLA
MATIN, A., XIE, Y., KAO, M., HUNG, M."RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU". International Journal of Oncology 6.5 (1995): 1087-1092.
Chicago
MATIN, A., XIE, Y., KAO, M., HUNG, M."RODENT P53 SUPPRESSES THE TRANSFORMING ACTIVITY OF THE ACTIVATED NEU ONCOGENE BY MODULATING THE BASAL PROMOTER ACTIVITY OF NEU". International Journal of Oncology 6, no. 5 (1995): 1087-1092. https://doi.org/10.3892/ijo.6.5.1087