ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION

  • Authors:
    • K JURIANZ
    • C HAAS
    • M HUBBE
    • C ERTEL
    • G BRUNNER
    • P ALTEVOGT
    • V SCHIRRMACHER
    • P VON HOEGEN
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.539
  • Pages: 539-545
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Abstract

Infection of metastatic lymphoma cells (ESbL) by a low dose of a non-lytic strain of Newcastle disease virus (NDV) leads to viral replication followed by strong cell surface expression of viral antigens, especially hemagglutinin neuraminidase (HN). The expressed HN was functional and facilitated cell-cell interactions and cell attachment. This was shown for NDV infected tumor cells, lymphocytes, fibroblasts and endothelial cells. The interactions could be strongly inhibited by antibodies against the viral HN protein. Increased binding was also seen with HN c-DNA transfectants expressing the HN as the only viral protein. Viral infection did not influence proliferation and lysability of the infected tumor cells. Following intravenous injection of tumor cells, the number of hepatic metastases was significantly reduced when the cells had been pre-infected with NDV. This reduction of metastases correlated with an increased survival time of the animals. As potential mechanisms of these NDV effects we propose augmentation of cell-eel interactions and immune functions and reduction of invasive capacity of NDV infected, as compared to non-infected tumor cells.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
JURIANZ K, HAAS C, HUBBE M, ERTEL C, BRUNNER G, ALTEVOGT P, SCHIRRMACHER V and VON HOEGEN P: ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. Int J Oncol 7: 539-545, 1995.
APA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P. ... VON HOEGEN, P. (1995). ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. International Journal of Oncology, 7, 539-545. https://doi.org/10.3892/ijo.7.3.539
MLA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7.3 (1995): 539-545.
Chicago
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7, no. 3 (1995): 539-545. https://doi.org/10.3892/ijo.7.3.539