MUTATIONAL ANALYSIS OF THE TUMOR-SUPPRESSOR GENE WT1 - DETECTION OF A NOVEL HOMOZYGOUS POINT MUTATION IN SPORADIC UNILATERAL WILMS-TUMOR

  • Authors:
    • R KOSTERS
    • V ADAMS
    • S HASSAM
    • R SCHAFER
    • M SCHMID
    • R MOOS
    • J BRINER
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1103
  • Pages: 1103-1107
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Abstract

The WT1 gene located on chromosome 11p13, has been identified as the first Wilms' tumor suppressor gene and has been implicated in the development of Wilms' tumor. About 10% of Wilms' tumors analyzed to date carry a mutation and only 6 different point mutations affecting the zinc finger region have been reported. We analyzed the zinc finger coding exons of 38 sporadic Wilms' tumor by SSCP and detected 2 point mutations. One homo/hemizygous mutation, already described in the literature, replaced an arginine in zinc finger II by a stop codon. The other mutation, a replacement of an arginine by a stop codon in zinc finger I, represents a novel mutation.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KOSTERS R, ADAMS V, HASSAM S, SCHAFER R, SCHMID M, MOOS R and BRINER J: MUTATIONAL ANALYSIS OF THE TUMOR-SUPPRESSOR GENE WT1 - DETECTION OF A NOVEL HOMOZYGOUS POINT MUTATION IN SPORADIC UNILATERAL WILMS-TUMOR. Int J Oncol 7: 1103-1107, 1995.
APA
KOSTERS, R., ADAMS, V., HASSAM, S., SCHAFER, R., SCHMID, M., MOOS, R., & BRINER, J. (1995). MUTATIONAL ANALYSIS OF THE TUMOR-SUPPRESSOR GENE WT1 - DETECTION OF A NOVEL HOMOZYGOUS POINT MUTATION IN SPORADIC UNILATERAL WILMS-TUMOR. International Journal of Oncology, 7, 1103-1107. https://doi.org/10.3892/ijo.7.5.1103
MLA
KOSTERS, R., ADAMS, V., HASSAM, S., SCHAFER, R., SCHMID, M., MOOS, R., BRINER, J."MUTATIONAL ANALYSIS OF THE TUMOR-SUPPRESSOR GENE WT1 - DETECTION OF A NOVEL HOMOZYGOUS POINT MUTATION IN SPORADIC UNILATERAL WILMS-TUMOR". International Journal of Oncology 7.5 (1995): 1103-1107.
Chicago
KOSTERS, R., ADAMS, V., HASSAM, S., SCHAFER, R., SCHMID, M., MOOS, R., BRINER, J."MUTATIONAL ANALYSIS OF THE TUMOR-SUPPRESSOR GENE WT1 - DETECTION OF A NOVEL HOMOZYGOUS POINT MUTATION IN SPORADIC UNILATERAL WILMS-TUMOR". International Journal of Oncology 7, no. 5 (1995): 1103-1107. https://doi.org/10.3892/ijo.7.5.1103