Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma

  • Authors:
    • M Baba
    • T Hideshima
    • T Shinohara
    • J Yamashita
    • T Shirakusa
  • View Affiliations

  • Published online on: February 1, 1996     https://doi.org/10.3892/ijo.8.2.355
  • Pages: 355-358
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Abstract

We analyzed the expression of bcl-2 and p53 in relation to clinicopathological features and estrogen receptor (ER) status in breast carcinomas from a series of 67 women who were treated surgically. Fifty and 23 cases showed positive immunostaining for bcl-2 and p53 protein, respectively. Thirty-five cases were ER-positive. A positive relationship was observed between bcl-2 and ER (p<0.05). Furthermore, an inverse relationship was observed between bcl-2 and p53 (p<0.01), which suggests that overexpression of p53 may down-regulate bcl-2 expression in breast carcinoma tissue, as has been described in a breast carcinoma cell line.

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February 1996
Volume 8 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Baba M, Hideshima T, Shinohara T, Yamashita J and Shirakusa T: Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma. Int J Oncol 8: 355-358, 1996.
APA
Baba, M., Hideshima, T., Shinohara, T., Yamashita, J., & Shirakusa, T. (1996). Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma. International Journal of Oncology, 8, 355-358. https://doi.org/10.3892/ijo.8.2.355
MLA
Baba, M., Hideshima, T., Shinohara, T., Yamashita, J., Shirakusa, T."Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma". International Journal of Oncology 8.2 (1996): 355-358.
Chicago
Baba, M., Hideshima, T., Shinohara, T., Yamashita, J., Shirakusa, T."Immunohistochemical analysis of bcl-2 and p53 protein in breast carcinoma". International Journal of Oncology 8, no. 2 (1996): 355-358. https://doi.org/10.3892/ijo.8.2.355