Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer

  • Authors:
    • C Latham
    • S Maner
    • H Blegen
    • E Eriksson
    • P Zickert
    • G Auer
    • A Zetterberg
  • View Affiliations

  • Published online on: February 1, 1996     https://doi.org/10.3892/ijo.8.2.359
  • Pages: 359-365
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Abstract

Many studies have noted an association between amplification of single oncogenes and poor prognosis in breast cancer. We are investigating whether measurement of amplification in a larger number of proto-oncogenes increases the reliability of the prognostic information provided. As the first stage of this investigation, amplification (of c-erbB-2, cycD1, int-2, c-myc and MDM2), aneuploidy and altered expression of p53, which all indicate genetic instability, were studied in 117 primary breast adenocarcinomas. Amplification was correlated with aneuploidy (p=0.002) but not with altered expression of p53 even though the tumours with p53 overexpression were all aneuploid. Our results suggest that measurement of amplification is a potentially valuable prognostic factor.

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February 1996
Volume 8 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Latham C, Maner S, Blegen H, Eriksson E, Zickert P, Auer G and Zetterberg A: Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer. Int J Oncol 8: 359-365, 1996.
APA
Latham, C., Maner, S., Blegen, H., Eriksson, E., Zickert, P., Auer, G., & Zetterberg, A. (1996). Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer. International Journal of Oncology, 8, 359-365. https://doi.org/10.3892/ijo.8.2.359
MLA
Latham, C., Maner, S., Blegen, H., Eriksson, E., Zickert, P., Auer, G., Zetterberg, A."Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer". International Journal of Oncology 8.2 (1996): 359-365.
Chicago
Latham, C., Maner, S., Blegen, H., Eriksson, E., Zickert, P., Auer, G., Zetterberg, A."Relationship between oncogene amplification, aneuploidy and altered expression of p53 in breast cancer". International Journal of Oncology 8, no. 2 (1996): 359-365. https://doi.org/10.3892/ijo.8.2.359