CD44 with variant exons 8-10 in colorectal tumors
- T Goi
- A Yamaguchi
- K Takeuchi
- G Nakagawa
- S Yamashiro
- K Furukawa
- T Urano
- H Shiku
Affiliations: NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN. FUKUI MED SCH,DEPT SURG 1,FUKUI 91011,JAPAN. MIE UNIV,SCH MED,DEPT INTERNAL MED 2,TSU,MIE 514,JAPAN.
- Published online on: April 1, 1996 https://doi.org/10.3892/ijo.8.4.657
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Using a fusion protein encoded by variant exon (v) 8-10 of CD44, a monoclonal antibody (mAb) 44-1V reactive with v9 product was generated. Western immunoblots and reverse transcriptase-polymerase chain reaction/Southern blot revealed that a 130 kilodalton component containing v8-10 products was specifically expressed in colorectal and gastric cancer cell lines. Immunohistological examination of 179 pairs of colorectal cancer and normal tissues revealed that about 47% of cancers expressed the CD44 variant (CD44v8-10), and its expression correlated with hematogenous and lymph node metastasis. These findings suggest the usefulness of CD44v8-10 in the prediction of colorectal cancer metastasis.