CD44 with variant exons 8-10 in colorectal tumors

  • Authors:
    • T Goi
    • A Yamaguchi
    • K Takeuchi
    • G Nakagawa
    • S Yamashiro
    • K Furukawa
    • T Urano
    • H Shiku
  • View Affiliations

  • Published online on: April 1, 1996     https://doi.org/10.3892/ijo.8.4.657
  • Pages: 657-662
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Abstract

Using a fusion protein encoded by variant exon (v) 8-10 of CD44, a monoclonal antibody (mAb) 44-1V reactive with v9 product was generated. Western immunoblots and reverse transcriptase-polymerase chain reaction/Southern blot revealed that a 130 kilodalton component containing v8-10 products was specifically expressed in colorectal and gastric cancer cell lines. Immunohistological examination of 179 pairs of colorectal cancer and normal tissues revealed that about 47% of cancers expressed the CD44 variant (CD44v8-10), and its expression correlated with hematogenous and lymph node metastasis. These findings suggest the usefulness of CD44v8-10 in the prediction of colorectal cancer metastasis.

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April 1996
Volume 8 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Goi, T., Yamaguchi, A., Takeuchi, K., Nakagawa, G., Yamashiro, S., Furukawa, K. ... Shiku, H. (1996). CD44 with variant exons 8-10 in colorectal tumors. International Journal of Oncology, 8, 657-662. https://doi.org/10.3892/ijo.8.4.657
MLA
Goi, T., Yamaguchi, A., Takeuchi, K., Nakagawa, G., Yamashiro, S., Furukawa, K., Urano, T., Shiku, H."CD44 with variant exons 8-10 in colorectal tumors". International Journal of Oncology 8.4 (1996): 657-662.
Chicago
Goi, T., Yamaguchi, A., Takeuchi, K., Nakagawa, G., Yamashiro, S., Furukawa, K., Urano, T., Shiku, H."CD44 with variant exons 8-10 in colorectal tumors". International Journal of Oncology 8, no. 4 (1996): 657-662. https://doi.org/10.3892/ijo.8.4.657