Accelerated neoadjuvant chemotherapy of non-small cell lung cancer (NSCLC)

  • Authors:
    • V Lorusso
    • F Carpagnano
    • G diRienzo
    • A Catino
    • M Cisternino
    • M Guida
    • M Brandi
    • A Latorre
    • S Parisi
    • R Ricco
    • M deLena
  • View Affiliations

  • Published online on: April 1, 1996     https://doi.org/10.3892/ijo.8.4.675
  • Pages: 675-680
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Abstract

Thirty patients with marginally resectable stage IIIA or stage IIIB NSCLC were treated with cisplatin (80 mg/ m(2)/i.v./dl), ifosfamide (4,000 mg/m(2)/i.v./dl) and vinorelbine (30 mg/m(2)/i.v./dl) plus G-CSF 300 mu g/s.c. on days 7-12 every 14 days for three cycles before surgery. In 26 evaluable patients, the radiographically assessed response rate to chemotherapy was 77% (8% complete). Three septic deaths (10%) occurred in spite of G-CSF and 1 patient refused to continue after the first cycle. Thoracothomy was performed in 23 patients including 19 complete resections. At 15 months median follow-up (range 10-22+), 11/19 (57%) completely resected patients relapsed. The overall median time to treatment failure was 11 months (range 0-17). Actuarial survival probability at 12, 18 and 24 months are 56%, 43% and 36%, respectively. In conclusion, the combination of cisplatin, ifosfamide and vinorelbine in full doses at a 14 day interval (accelerated chemotherapy) was very effective in neoadjuvant NSCLC setting. Nevertheless, relevant toxicity was demonstrated with a 10% death rate probably due to the overlapping toxicity of chemotherapy cycles, suggesting the need for a more intense supportive care or longer interval between cycles.

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April 1996
Volume 8 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Lorusso, V., Carpagnano, F., diRienzo, G., Catino, A., Cisternino, M., Guida, M. ... deLena, M. (1996). Accelerated neoadjuvant chemotherapy of non-small cell lung cancer (NSCLC). International Journal of Oncology, 8, 675-680. https://doi.org/10.3892/ijo.8.4.675
MLA
Lorusso, V., Carpagnano, F., diRienzo, G., Catino, A., Cisternino, M., Guida, M., Brandi, M., Latorre, A., Parisi, S., Ricco, R., deLena, M."Accelerated neoadjuvant chemotherapy of non-small cell lung cancer (NSCLC)". International Journal of Oncology 8.4 (1996): 675-680.
Chicago
Lorusso, V., Carpagnano, F., diRienzo, G., Catino, A., Cisternino, M., Guida, M., Brandi, M., Latorre, A., Parisi, S., Ricco, R., deLena, M."Accelerated neoadjuvant chemotherapy of non-small cell lung cancer (NSCLC)". International Journal of Oncology 8, no. 4 (1996): 675-680. https://doi.org/10.3892/ijo.8.4.675