Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma

  • Authors:
    • Y Takahashi
    • M Mai
    • M Wilson
    • Y Kitadai
    • C Bucana
    • L Ellis
  • View Affiliations

  • Published online on: April 1, 1996     https://doi.org/10.3892/ijo.8.4.701
  • Pages: 701-705
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Abstract

To determine the role of site of tumor implantation on tumor angiogenesis, we implanted gastric cancer cells in the orthotopic (stomach) and ectopic (subcutaneous) locations in nude mice. Tumors in the stomach demonstrated greater vascularization, higher levels of vascular endothelial growth factor (VEGF) expression, and greater proliferation compared with tumors in the subcutaneous tissues. These data suggest that the relationships among the expression of VEGF, vascularization, and proliferation of human gastric cancer cells are regulated by the organ microenvironment. In addition, VEGF may provide a target for anti-angiogenic therapy for gastric cancers.

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April 1996
Volume 8 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Takahashi, Y., Mai, M., Wilson, M., Kitadai, Y., Bucana, C., & Ellis, L. (1996). Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma. International Journal of Oncology, 8, 701-705. https://doi.org/10.3892/ijo.8.4.701
MLA
Takahashi, Y., Mai, M., Wilson, M., Kitadai, Y., Bucana, C., Ellis, L."Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma". International Journal of Oncology 8.4 (1996): 701-705.
Chicago
Takahashi, Y., Mai, M., Wilson, M., Kitadai, Y., Bucana, C., Ellis, L."Site-dependent expression of vascular endothelial growth factor, angiogenesis and proliferation in human gastric carcinoma". International Journal of Oncology 8, no. 4 (1996): 701-705. https://doi.org/10.3892/ijo.8.4.701