Urinary markers for prostate cancer
- M Abdul
- M Banks
- N Hoosein
Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT GENITOURINARY MED ONCOL,HOUSTON,TX 77030.
- Published online on: April 1, 1996 https://doi.org/10.3892/ijo.8.4.735
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Immunoglobulins (Igs), bombesin-like immunoreactivity (BLI), beta-2 microglobulin (beta-2m) and transferrin were measured by radioimmunoassay in the first voided urine of patients with advanced prostatic carcinoma. Compared to 16 age-matched, healthy subjects, urinary Igs were elevated in 19 (48%), BLI in 12 (30%), beta-2m in 29 (74%) and transferrin in 8 (20%) of 40 adenocarcinoma patients. Elevation in urinary Igs, BLI or beta-2m was associated with a significantly shorter survival. The four urine markers correlated well with serum chromogranin A but not with serum prostate-specific antigen. Results suggest that these urine markers are elevated with high frequency in advanced prostate cancer.