Sequential expression of myc-, ras-, oncogene products and EGF receptor during DMBA-induced tongue carcinogenesis

  • Authors:
    • S Shintani
    • T Matsumura
    • R Alcalde
    • Y Yoshihama
  • View Affiliations

  • Published online on: April 1, 1996     https://doi.org/10.3892/ijo.8.4.821
  • Pages: 821-826
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Abstract

The mechanism leading to development of oral cancer has not been completely understood. It is currently believed that alternation of a number of genes can result in the development of epidermoid carcinomas. In this investigation, we used a 9,10-dimethyl 1,2-benzanthracene (DMBA)-induced carcinogenesis in a hamster tongue model to investigate the expression of c-myc, c-Ha-ms proteins and epidermal growth factor receptor (EGFr). During the DMBA-carcinogenesis of the tongue, the number of c-myc protein positive cells were increased in epithelial dysplasia and elevated throughout the process of tumorigenesis. The expression of c-Ha-ras protein was detected in normal epithelium. The level of c-Ha-ras protein expression was decreased in the dysplastic stage, and it was almost negative in squamous cell carcinomas. Detection of EGFr overexpression occurred only after 1-4 weeks of DMBA treatment, at a very early stage of tumor development, and increased through carcinogenesis varying individually within the malignant tissues. These results suggest that c-myc protein and c-Ha-ras protein expression may have an important role in malignant transformation, and the overexpression of EGFr can be correlated to very early stages of tumor development in the DMBA-induced in vivo tongue carcinogenesis.

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April 1996
Volume 8 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Shintani, S., Matsumura, T., Alcalde, R., & Yoshihama, Y. (1996). Sequential expression of myc-, ras-, oncogene products and EGF receptor during DMBA-induced tongue carcinogenesis. International Journal of Oncology, 8, 821-826. https://doi.org/10.3892/ijo.8.4.821
MLA
Shintani, S., Matsumura, T., Alcalde, R., Yoshihama, Y."Sequential expression of myc-, ras-, oncogene products and EGF receptor during DMBA-induced tongue carcinogenesis". International Journal of Oncology 8.4 (1996): 821-826.
Chicago
Shintani, S., Matsumura, T., Alcalde, R., Yoshihama, Y."Sequential expression of myc-, ras-, oncogene products and EGF receptor during DMBA-induced tongue carcinogenesis". International Journal of Oncology 8, no. 4 (1996): 821-826. https://doi.org/10.3892/ijo.8.4.821