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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1996 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 1996 Volume 9 Issue 1

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Article

Intrasplenic vaccination against experimental melanoma

  • Authors:
    • D Shrayer
    • C Park
    • N Kouttab
    • H Bogaars
    • R McInnis
    • S Paul
    • A Maizel
    • V Hearing
    • H Wanebo

  • View Affiliations / Copyright

    Affiliations: ROGER WILLIAMS MED CTR,DEPT SURG,PROVIDENCE,RI 02908. BROWN UNIV,RHODE ISL HOSP,DEPT PEDIAT,PROVIDENCE,RI 02908. NCI,CELL BIOL LAB,NIH,BETHESDA,MD 20892.
  • Pages: 123-129
    |
    Published online on: July 1, 1996
       https://doi.org/10.3892/ijo.9.1.123
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Abstract

The immunodominant component of a formalinized extracellular antigen (fECA) vaccine prepared from B16 F10 melanoma cells is the melanoma-associated antigen B700. We now demonstrate that a single prophylactic intrasplenic inoculation of B700 antigen (1-10 mu g) stimulates the production of antibodies which have antiproliferative effects on B16 F10 melanoma cells in vitro. In addition, potential cytotoxic effects of splenocytes from B700 antigen inoculated mice were evaluated for two cellular immune effector functions, natural killer (NK) cell activity and lymphokine activated killer (LAK) cell activity; both activities were increased following B700 antigen inoculation. Intrasplenic injection of B700 antigen elicited an increase in the expression of the CD25 surface antigen (IL-2 R alpha) by T lymphocytes and up-regulated the expression of IL-2 R alpha mRNA. Thus both humoral and cellular cytotoxic immune responses might play roles in the decreased growth of primary tumors in B700 antigen inoculated mice and in the higher survival rate in this group of animals.

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Copy and paste a formatted citation
Spandidos Publications style
Shrayer D, Park C, Kouttab N, Bogaars H, McInnis R, Paul S, Maizel A, Hearing V and Wanebo H: Intrasplenic vaccination against experimental melanoma. Int J Oncol 9: 123-129, 1996.
APA
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S. ... Wanebo, H. (1996). Intrasplenic vaccination against experimental melanoma. International Journal of Oncology, 9, 123-129. https://doi.org/10.3892/ijo.9.1.123
MLA
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S., Maizel, A., Hearing, V., Wanebo, H."Intrasplenic vaccination against experimental melanoma". International Journal of Oncology 9.1 (1996): 123-129.
Chicago
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S., Maizel, A., Hearing, V., Wanebo, H."Intrasplenic vaccination against experimental melanoma". International Journal of Oncology 9, no. 1 (1996): 123-129. https://doi.org/10.3892/ijo.9.1.123
Copy and paste a formatted citation
x
Spandidos Publications style
Shrayer D, Park C, Kouttab N, Bogaars H, McInnis R, Paul S, Maizel A, Hearing V and Wanebo H: Intrasplenic vaccination against experimental melanoma. Int J Oncol 9: 123-129, 1996.
APA
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S. ... Wanebo, H. (1996). Intrasplenic vaccination against experimental melanoma. International Journal of Oncology, 9, 123-129. https://doi.org/10.3892/ijo.9.1.123
MLA
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S., Maizel, A., Hearing, V., Wanebo, H."Intrasplenic vaccination against experimental melanoma". International Journal of Oncology 9.1 (1996): 123-129.
Chicago
Shrayer, D., Park, C., Kouttab, N., Bogaars, H., McInnis, R., Paul, S., Maizel, A., Hearing, V., Wanebo, H."Intrasplenic vaccination against experimental melanoma". International Journal of Oncology 9, no. 1 (1996): 123-129. https://doi.org/10.3892/ijo.9.1.123
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