Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome

  • Authors:
    • P Georgiou
    • I Maroulakou
    • J Green
    • P Dantis
    • V Romano-Spica
    • S Kottaridis
    • J Lautenberger
    • D Watson
    • T Papas
    • P Fischinger
    • N Bhat
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/ijo.9.1.9
  • Pages: 9-18
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Abstract

We have examined the expression of three members of the ets family of genes, ETS1, ETS2 and ERGB/Fli-1, in lymphocytes from patients with systemic lupus erythematosus and in two murine autoimmune model systems. The ERGB/Fli-1 gene is expressed at a higher level in lymphocytes from autoimmune disease patients than healthy individuals. In addition, we found that the ERGB/Fli-1 gene expression is higher in splenic T-cells from lupus prone mice and in infiltrating lymphocytes in the salivary glands of HTLV-I tax transgenic mice. Taken together, these results suggest that the elevated expression of the ERGB/Fli-1 gene in lymphocytes may be a prelude to the development of autoimmune diseases.

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July 1996
Volume 9 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Georgiou P, Maroulakou I, Green J, Dantis P, Romano-Spica V, Kottaridis S, Lautenberger J, Watson D, Papas T, Fischinger P, Fischinger P, et al: Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome. Int J Oncol 9: 9-18, 1996
APA
Georgiou, P., Maroulakou, I., Green, J., Dantis, P., Romano-Spica, V., Kottaridis, S. ... Bhat, N. (1996). Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome. International Journal of Oncology, 9, 9-18. https://doi.org/10.3892/ijo.9.1.9
MLA
Georgiou, P., Maroulakou, I., Green, J., Dantis, P., Romano-Spica, V., Kottaridis, S., Lautenberger, J., Watson, D., Papas, T., Fischinger, P., Bhat, N."Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome". International Journal of Oncology 9.1 (1996): 9-18.
Chicago
Georgiou, P., Maroulakou, I., Green, J., Dantis, P., Romano-Spica, V., Kottaridis, S., Lautenberger, J., Watson, D., Papas, T., Fischinger, P., Bhat, N."Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome". International Journal of Oncology 9, no. 1 (1996): 9-18. https://doi.org/10.3892/ijo.9.1.9