Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells

  • Authors:
    • Y Niinaka
    • S Oida
    • A Ishisaki
    • K Takeda
    • T Iimura
    • Y Maruoka
    • F Momose
    • A Negishi
    • H Ichijo
    • T Amagasa
    • S Sasaki
    • H Watanabe
    • A Raz
  • View Affiliations

  • Published online on: September 1, 1996     https://doi.org/10.3892/ijo.9.3.433
  • Pages: 433-438
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Abstract

Autocrine motility factor (AMF) a tumor-secreted 55 kDa cytokine induces tumor cell motility by a signal transduction pathway mediated by interaction with its receptor (AMFR) a cell surface glycoprotein of 78 kDa (gp78). Here, AMF secreted by the metastatic LMF4 human oral squamous-cell carcinoma (SCC) cells, induced dose- and time-dependent morphological changes and chemotaxis of the producing cells. Expression of AMFR mRNA was associated with the metastatic ability of SCC cell variants. The data presented show for the first time that SCC cells produce AMF and express AMFR and the expression is related to their invasiveness and metastatic potentials.

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September 1996
Volume 9 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Niinaka Y, Oida S, Ishisaki A, Takeda K, Iimura T, Maruoka Y, Momose F, Negishi A, Ichijo H, Amagasa T, Amagasa T, et al: Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells. Int J Oncol 9: 433-438, 1996
APA
Niinaka, Y., Oida, S., Ishisaki, A., Takeda, K., Iimura, T., Maruoka, Y. ... Raz, A. (1996). Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells. International Journal of Oncology, 9, 433-438. https://doi.org/10.3892/ijo.9.3.433
MLA
Niinaka, Y., Oida, S., Ishisaki, A., Takeda, K., Iimura, T., Maruoka, Y., Momose, F., Negishi, A., Ichijo, H., Amagasa, T., Sasaki, S., Watanabe, H., Raz, A."Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells". International Journal of Oncology 9.3 (1996): 433-438.
Chicago
Niinaka, Y., Oida, S., Ishisaki, A., Takeda, K., Iimura, T., Maruoka, Y., Momose, F., Negishi, A., Ichijo, H., Amagasa, T., Sasaki, S., Watanabe, H., Raz, A."Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells". International Journal of Oncology 9, no. 3 (1996): 433-438. https://doi.org/10.3892/ijo.9.3.433