Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo

  • Authors:
    • D Lopez
    • A House
  • View Affiliations

  • Published online on: October 1, 1996     https://doi.org/10.3892/ijo.9.4.815
  • Pages: 815-819
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A protocol for tumour cell inoculation (Per192NR and Per237 rat colon cancer cells) and implantation of mini-osmotic pumps in inbred rats was established. Surgical procedures and tumour growth did not affect red and white blood cell counts. Per237 did not grow in these rats while Per192NR formed poorly differentiated carcinomas which were not affected by EGF intraperitoneal (IP) or intravenous (IV), oleic acid (IP) or verapamil (IP or oral) administration. Haematological parameters and rat growth rates were not affected by EGF (IP and IV), verapamil (IP) and oleic acid (IP) treatment. This protocol provides a method for studying the effect of various cancer drugs in vivo.

Related Articles

Journal Cover

October 1996
Volume 9 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lopez D and Lopez D: Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo. Int J Oncol 9: 815-819, 1996
APA
Lopez, D., & Lopez, D. (1996). Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo. International Journal of Oncology, 9, 815-819. https://doi.org/10.3892/ijo.9.4.815
MLA
Lopez, D., House, A."Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo". International Journal of Oncology 9.4 (1996): 815-819.
Chicago
Lopez, D., House, A."Effects of epidermal growth factor and mitogenic blockers on rat colonic tumour growth in vivo". International Journal of Oncology 9, no. 4 (1996): 815-819. https://doi.org/10.3892/ijo.9.4.815