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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1996 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 1996 Volume 9 Issue 5

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Article

Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells

  • Authors:
    • D Fan
    • P Beltran
    • Y Wang
    • C Bucana
    • S Yoon
    • A Deguzman
    • I Fidler

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CELL BIOL,HOUSTON,TX 77030.
  • Pages: 865-878
    |
    Published online on: November 1, 1996
       https://doi.org/10.3892/ijo.9.5.865
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Abstract

We studied the regulation of mdr-1 and P-glycoprotein in sparse and confluent cultures of murine CT-26 colon carcinoma cells. The expression level of mdr-1 mRNA transcripts (analyzed by Northern blot and in situ hybridization) and P-glycoprotein (analyzed by flow cytometry) inversely correlated with cell density. The modulation of mdr gene expression in sparse and confluent cells was not related to cell division, nutrient depletion, inhibition of protein synthesis, gap junction status, extracellular ATP, or the presence of various extracellular matrixes, but may be related to cell-density and cell-contact mediated changes in phosphatase activity. The confluence-mediated downmodulation of mdr-1 increased the chemosensitivity of the cells to several anticancer drugs commonly associated with an in vitro MDR phenotype by increasing the intracellular accumulation of the drugs. These data may explain some of the discrepancies in results obtained when analyzing mdr gene expression in tumors growing in vivo or in vitro, and why mdi expression in tumors is localized to the periphery of the lesions.

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Copy and paste a formatted citation
Spandidos Publications style
Fan D, Beltran P, Wang Y, Bucana C, Yoon S, Deguzman A and Fidler I: Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells. Int J Oncol 9: 865-878, 1996.
APA
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., & Fidler, I. (1996). Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells. International Journal of Oncology, 9, 865-878. https://doi.org/10.3892/ijo.9.5.865
MLA
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., Fidler, I."Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells". International Journal of Oncology 9.5 (1996): 865-878.
Chicago
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., Fidler, I."Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells". International Journal of Oncology 9, no. 5 (1996): 865-878. https://doi.org/10.3892/ijo.9.5.865
Copy and paste a formatted citation
x
Spandidos Publications style
Fan D, Beltran P, Wang Y, Bucana C, Yoon S, Deguzman A and Fidler I: Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells. Int J Oncol 9: 865-878, 1996.
APA
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., & Fidler, I. (1996). Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells. International Journal of Oncology, 9, 865-878. https://doi.org/10.3892/ijo.9.5.865
MLA
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., Fidler, I."Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells". International Journal of Oncology 9.5 (1996): 865-878.
Chicago
Fan, D., Beltran, P., Wang, Y., Bucana, C., Yoon, S., Deguzman, A., Fidler, I."Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells". International Journal of Oncology 9, no. 5 (1996): 865-878. https://doi.org/10.3892/ijo.9.5.865
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