Modulation of cisplatin sensitivity and resistance by buthionine sulfoximine and cyclosporin A in human esophageal cancer cells

Tanaka,N; Aizawa,K; Katayanagi,N; Yabusaki,H; Suzuki,T; Tanaka,O

doi:10.3892/ijo.9.5.935

Modulation of cisplatin sensitivity and resistance by buthionine sulfoximine and cyclosporin A in human esophageal cancer cells

Authors:
- N Tanaka
- K Aizawa
- N Katayanagi
- H Yabusaki
- T Suzuki
- O Tanaka
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Affiliations: NIIGATA CITY GEN HOSP,DEPT SURG 1,NIIGATA 950,JAPAN. NIIGATA CANC CTR HOSP,DIV SURG,NIIGATA 951,JAPAN.
Published online on: November 1, 1996 https://doi.org/10.3892/ijo.9.5.935
Pages: 935-940

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Abstract

We established a 2.4-fold cisplatin (CDDP)-resistant human esophageal cancer cell line (TE2R) from the parent TE2 line. CDDP accumulation was reduced in TE2R. The Na+, K+-ATPase inhibitor ouabain inhibited CDDP accumulation in TE2 but not TE2R, suggesting that TE2R may have alterations in the Na+, K+-ATPase and defective CDDP uptake mechanism. Buthionine sulfoximine (BSO) enhanced CDDP sensitivity of both cell lines and cyclosporin A (CsA) modified CDDP resistance in TE2R. These effects were associated with increased CDDP accumulation. Thus, BSO and CsA may be useful for modulation of CDDP sensitivity or resistance in esophageal cancer.