Pneumothorax following combination chemotherapy with bevacizumab: A case report and review of the literature

Alrifai,Taha; Saba,Raya; Rifai,Dana; Pandit,Sarbagya; Kozma,Kelley  E.

doi:10.3892/mco.2019.1868

Pneumothorax following combination chemotherapy with bevacizumab: A case report and review of the literature

Authors:
- Taha Alrifai
- Raya Saba
- Dana Rifai
- Sarbagya Pandit
- Kelley E. Kozma
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Affiliations: Department of Internal Medicine, Saint Joseph Hospital, Chicago, IL 60657, USA, Department of Hospital Medicine, John T. Milliken Department of Medicine, Washington University, St. Louis, MO 63110, USA, Department of Internal Medicine, St. Catherine Hospital, East Chicago, IN 46312, USA, Department of Hematology and Oncology, Saint Joseph Hospital, Chicago, IL 60657, USA
Published online on: May 28, 2019 https://doi.org/10.3892/mco.2019.1868
Pages: 173-176

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Abstract

Bevacizumab (BV) is a humanized monoclonal antibody that inhibits angiogenesis by targeting vascular endothelial growth factor (VEGF). The addition of BV to combination chemotherapy has been shown to improve the outcomes in several malignancies, including colorectal carcinoma (CRC). However, the use of BV has been associated with adverse effects, including hypertension, hemorrhage, proteinuria, delayed wound healing and bowel perforation. Pneumothorax (PTX) as an adverse event associated with BV use has rarely been reported. We herein report the case of a 68‑year‑old female patient with a history of metastatic CRC treated with combination chemotherapy, including BV, who presented with complaints of shortness of breath and was found to have a right‑sided PTX.

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