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Differentiation between benign and malignant ovarian masses in the preoperative period using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios

  • Authors:
    • Melahat Yildirim
    • Busra Demir Cendek
    • Ayse Filiz Avsar

  • View Affiliations

  • Published online on: December 24, 2014     https://doi.org/10.3892/mco.2014.481
  • Pages: 317-321

  • Copyright: © Yildirim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to evaluate the association between preoperative neutrophil‑to‑lymphocyte ratio (NLR) and platelet‑to‑lymphocyte ratio (PLR) and the pathological diagnosis of adnexal masses. The predictive effect of inflammatory markers on epithelial ovarian cancer was also investigated. The present study included a total of 306 patients with adnexal masses who underwent surgical resection and the diagnosis was based on pathological investigation. The patients were divided into six groups based on their pathological findings and compared with respect to their NLR and PLR values. We used receiver‑operating characteristic curves to calculate optimal cut‑off values for NLR and PLR to predict ovarian cancer preoperatively. Patients with ovarian cancer exhibited significantly higher NLR and PLR values (P<0.05 and P<0.001, respectively). The multivariate analysis demonstrated that higher NLR and PLR values predicted ovarian cancer at the cut‑off value of 3.35, sensitivity of 55% and specificity of 81% for NLR [95% confidence interval (CI): 0.544‑0.752, P<0.05] and at the cut‑off value of 572.9, sensitivity of 100% and specificity of 0.38% for PLR (95% CI: 0.192‑0.381, P=0.001). Therefore, preoperative NLR and PLR values may help identify ovarian cancer in patients with adnexal masses.
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Spandidos Publications style
Yildirim M, Cendek BD and Avsar AF: Differentiation between benign and malignant ovarian masses in the preoperative period using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios. Mol Clin Oncol 3: 317-321, 2015
APA
Yildirim, M., Cendek, B.D., & Avsar, A.F. (2015). Differentiation between benign and malignant ovarian masses in the preoperative period using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios. Molecular and Clinical Oncology, 3, 317-321. https://doi.org/10.3892/mco.2014.481
MLA
Yildirim, M., Cendek, B. D., Avsar, A. F."Differentiation between benign and malignant ovarian masses in the preoperative period using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios". Molecular and Clinical Oncology 3.2 (2015): 317-321.
Chicago
Yildirim, M., Cendek, B. D., Avsar, A. F."Differentiation between benign and malignant ovarian masses in the preoperative period using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios". Molecular and Clinical Oncology 3, no. 2 (2015): 317-321. https://doi.org/10.3892/mco.2014.481