High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer

  • Authors:
    • Doonyapat Sa‑Nguanraksa
    • Tuenjai Chuangsuwanich
    • Tawatchai Pongpruttipan
    • Pornchai O‑Charoenrat
  • View Affiliations

  • Published online on: June 9, 2015     https://doi.org/10.3892/mco.2015.574
  • Pages: 1103-1108
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Abstract

Breast cancer is the most frequent type of cancer among women worldwide. Vascular endothelial growth factor (VEGF), the key modulator of angiogenesis, has been implicated in breast cancer susceptibility and aggressiveness. VEGF expression was determined in 99 breast cancer tissue samples using reverse transcription‑polymerase chain reaction and the human epidermal growth factor receptor 2 (HER2) status was determined by immunohistochemistry. Subsequently, the associations of VEGF, HER2 and hormone receptor status with clinicopathological data were evaluated. High VEGF expression was found to be significantly correlated with the presence of lymphovascular invasion. In hormone receptor‑positive/HER2‑positive, HER2‑positive and triple‑negative breast cancer, high VEGF expression was correlated with the presence of axillary nodal metastasis and lower overall survival rates. Therefore, the assessment of the VEGF status along with the hormone receptor and HER2 status may help identify high‑risk patients who may benefit from anti-VEGF treatment.
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September-2015
Volume 3 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sa‑Nguanraksa D, Chuangsuwanich T, Pongpruttipan T and O‑Charoenrat P: High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer. Mol Clin Oncol 3: 1103-1108, 2015
APA
Sa‑Nguanraksa, D., Chuangsuwanich, T., Pongpruttipan, T., & O‑Charoenrat, P. (2015). High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer. Molecular and Clinical Oncology, 3, 1103-1108. https://doi.org/10.3892/mco.2015.574
MLA
Sa‑Nguanraksa, D., Chuangsuwanich, T., Pongpruttipan, T., O‑Charoenrat, P."High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer". Molecular and Clinical Oncology 3.5 (2015): 1103-1108.
Chicago
Sa‑Nguanraksa, D., Chuangsuwanich, T., Pongpruttipan, T., O‑Charoenrat, P."High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1103-1108. https://doi.org/10.3892/mco.2015.574