Extracranial oral cavity metastasis from glioblastoma multiforme: A case report

Introduction

Glioblastoma multiforme is a highly malignant glioma of astrocytic origin (1). The tumor is defined as grade IV according to the World Health Organization (WHO) classification, and is a cytologically malignant, mitotically active, necrosis-prone neoplasm, typically associated with rapid pre- and postoperative disease evolution and a fatal outcome, with a median survival of ~12 months (2,3).

With an incidence of 3.19/100.000 patient years, glioblastoma multiforme is the most common glioma in adults (typical age, 50–70 years), located mostly in the frontotemporal cerebral lobes (1,4).

The treatment of choice currently consists of maximal safe surgical resection and postoperative concomitant radiochemotherapy (RCTx), followed by further chemotherapy with the orally administered alkylating drug temozolomide (5). The indication for radiotherapy (RTx) depends on the patient's general condition [Karnofsky performance status (PS) or Eastern Cooperative Oncology Group PS], age and extent of surgery (6,7). Typically, conformal RTx consists of 54–60 Gy (1.8–2.0 Gy per fraction), with limited safety margins of a maximum 2.0 cm. Long-term local control is difficult to achieve. Extracranial metastases are reported to occur in 0.4–0.5% of all cases (8–12). In 1928, Davis first reported a patient with disseminated glioblastoma (13). The affected organs included the lung, upper extremity soft tissue and chest wall. The natural history of glioblastomas that metastasize to organs outside the central nervous system is largely unknown. Between 1928 and 2009, 88 cases of extracranial metastasis from glioblastoma (n=83) and gliosarcoma (n=5) have been published, reported and analyzed by Lun et al (14). In 2015, Pietschmann et al reviewed existing data and performed a new meta-analysis with 150 cases (15). In addition to brain stem and spinal axis, lymph nodes and visceral organs, including the liver, lung, pleura and bones, were found to be involved. In only one of all documented cases an extracranial oral cavity metastasis of significant extent and exhibiting rapid growth was described (16).

Case report

A 70-year-old female patient was admitted to our hospital suffering from progressive lack of concentration and cognitive deficit. The patient's husband also reported a personality change. Arterial hypertension, hyperthyroidism and lipometabolic disorder were documented, without other comorbidities. Initially, we performed magnetic resonance imaging (MRI) of the head, which revealed a massive tumor in the right frontal lobe, with perifocal oedema and midline dislocation of 6 mm, suspicious for glioblastoma (Fig. 1). The tumor was sized 4.2×2.8×3.9 cm. Navigated maximal safe tumor excision was performed with osteoplastic craniotomy and dura mater plastic surgery. The postoperative course was uneventful. Histology and immunohistochemical investigation revealed a O6-methylguanine-DNA methyltransferase-positive glioblastoma multiforme, WHO grade IV. Adjuvant RCTx was initially performed with low-dose temozolomide 140 mg/day, subsequently escalated to the standard dose of 200 mg/day (total dose 60 Gy, 2 Gy per fraction).

Figure 1. Preoperative magnetic resonance imaging. Left/middle: T1-weighted axial gadolinium-enhanced image showing an enhancing tumor of the right frontal lobe. Right: T2-weighted image showing the same lesion as in the previous images, with notable edema.

One year after the diagnosis, the patient developed a rapidly progressive oral cavity tumor, filling the entire buccal cavity within 2 weeks (Fig. 2). Following biopsy, the histological examination revealed a necrotic retromaxillary metastasis of the previously diagnosed glioblastoma, exhibiting histological characteristics identical to those of the primary resected tumor. Systemic metastases were not identified. The patient was unable to speak or eat (Fig. 3). Following extensive interdisciplinary discussion, we decided to proceed with local palliative RTx and supportive measures. The patient developed massive breathing difficulties, necessitating transfer to the intensive care unit, followed by tracheotomy and immediate mechanical ventilation. We first planned to administer a total of 45 Gy/3 Gy per fraction. In the light of rapid progress of the tumor, a dose of 5 Gy per fraction was applied (Fig. 3). However, after 4 applications, the patient's relatives requested discontinuation of RTx and the patient succumbed to the disease soon thereafter.

Figure 2. Computed tomography of the head performed during the second clinical presentation of the patient. A mass is identified in the right buccal space, without extension outside the skull base.

Figure 3. Left: Visible tumor mass in the right buccal cavity. Right: Picture of the patient during radiotherapy; the tumor mass is seen emerging from the buccal cavity.

Discussion

We herein report the case of a patient suffering from glioblastoma with subsequent retromaxillary metastatic spread completely filling the buccal cavity. Initial treatment with cranial tumor extirpation followed by RCTx with 60 Gy and temozolomide was performed. At the time of relapse and clinical deterioration, the patient was treated with 20 Gy to the metastatic area. However, RTx was discontinued and the patient succumbed to the disease soon thereafter. Extracranial metastasis from glioblastoma remains an uncommon finding (15). Thus far, a massive metastasis completely filling the buccal cavity has only been reported in 1996 by Horiuchi et al (16) in a 41-year-old female. In contrast to our patient, simultaneous local recurrence of the tumor was described. MRI and computed tomography scans revealed orbital, nasal and oral masses extending inferiorly from the recurrent tumor in the right temporal lobe through the anterior and middle skull base. The oral cavity tumor and swelling of the patient's face grew rapidly. The common characteristics of the two cases are rapid growth and gender of the patient, but no connection to cranial tissue was radiologically detected in our patient.

The reasons for such extensive spread in this particular location and the growth rate are not well understood. A necessary requirement for extracranial metastasis is tumor cells crossing the dura mater, which is the most important barrier. Surgery and radiation therapy may lead to dural damage and potentially facilitate extracranial extension. In our case, no lesion of the dura mater was documented during surgery. A ventricular systemic shunt was not indicated. Our 70-year-old patient underwent craniotomy followed by RTx with simultaneous chemotherapy. Younger patients exhibit an increased risk of extraneural involvement due to prolonged survival (15,17). The most common sites of extracranial metastases from glioblastoma are the lungs, bone (bone marrow), lymph nodes and soft tissues (14). This is the second report of an extracranial metastasis with a retromaxillary localization, exhibiting rapid growth and completely filling the buccal cavity. Glioblastoma is a tumor with fatal outcome. Although extracranial metastases remain extremely uncommon, extraneural spread of the tumor is possible and must be considered in symptomatic patients during follow-up. Extracranial glioblastomas may present with an extraordinarily rapid progression pattern, as in our case. Therefore, fast decision-making and treatment initiation are crucial for optimal palliative treatment. Further investigation is required to improve therapy and outcome.

References