Open Access

Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small‑cell lung cancer

  • Authors:
    • Masayuki Shirasawa
    • Yoshiro Nakahara
    • Hideyuki Niwa
    • Shinya Harada
    • Takahiro Ozawa
    • Seiichiro Kusuhara
    • Masashi Kasajima
    • Yasuhiro Hiyoshi
    • Jiichiro Sasaki
    • Noriyuki Masuda
  • View Affiliations

  • Published online on: October 26, 2016     https://doi.org/10.3892/mco.2016.1062
  • Pages: 714-716
  • Copyright: © Shirasawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pegfilgrastim is a long‑acting granulocyte colony‑stimulating factor formulation that has been approved for the prevention of febrile neutropenia. We herein report a case of interstitial pneumonia following administration of pegfilgrastim. A 65‑year‑old man with stage IV small‑cell lung cancer was treated with carboplatin and etoposide as third‑line chemotherapy. Pegfilgrastim was administered during the second cycle of chemotherapy. On the day after the administration of pegfilgrastim, interstitial pneumonia developed. The respiratory condition improved with pulse steroid therapy; however, the patient eventually succumbed to cancer progression. In conclusion, interstitial pneumonia due to pegfilgrastim is rare; however, physicians should be aware of the possibility of this adverse effect.
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December-2016
Volume 5 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Shirasawa M, Nakahara Y, Niwa H, Harada S, Ozawa T, Kusuhara S, Kasajima M, Hiyoshi Y, Sasaki J, Masuda N, Masuda N, et al: Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small‑cell lung cancer. Mol Clin Oncol 5: 714-716, 2016
APA
Shirasawa, M., Nakahara, Y., Niwa, H., Harada, S., Ozawa, T., Kusuhara, S. ... Masuda, N. (2016). Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small‑cell lung cancer. Molecular and Clinical Oncology, 5, 714-716. https://doi.org/10.3892/mco.2016.1062
MLA
Shirasawa, M., Nakahara, Y., Niwa, H., Harada, S., Ozawa, T., Kusuhara, S., Kasajima, M., Hiyoshi, Y., Sasaki, J., Masuda, N."Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small‑cell lung cancer". Molecular and Clinical Oncology 5.6 (2016): 714-716.
Chicago
Shirasawa, M., Nakahara, Y., Niwa, H., Harada, S., Ozawa, T., Kusuhara, S., Kasajima, M., Hiyoshi, Y., Sasaki, J., Masuda, N."Interstitial pneumonia following administration of pegfilgrastim during carboplatin and etoposide chemotherapy for small‑cell lung cancer". Molecular and Clinical Oncology 5, no. 6 (2016): 714-716. https://doi.org/10.3892/mco.2016.1062