Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well‑differentiated squamous cell carcinoma: A case report

Okuyama,Kohei; Fujita,Shuichi; Yanamoto,Souichi; Naruse,Tomofumi; Sakamoto,Yuki; Kawakita,Akiko; Omori,Keisuke; Tsuchihashi,Hiroki; Umeda,Masahiro

doi:10.3892/mco.2017.1323

Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well‑differentiated squamous cell carcinoma: A case report

Authors:
- Kohei Okuyama
- Shuichi Fujita
- Souichi Yanamoto
- Tomofumi Naruse
- Yuki Sakamoto
- Akiko Kawakita
- Keisuke Omori
- Hiroki Tsuchihashi
- Masahiro Umeda
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Affiliations: Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan, Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan
Published online on: July 13, 2017 https://doi.org/10.3892/mco.2017.1323
Pages: 341-346
Copyright: © Okuyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spindle cell carcinoma (SpCC), which predominantly arises in the oral, pharyngeal and laryngeal mucosal tissues, is composed of a mixture of squamous and sarcomatoid components. The present study describes the case of a 62‑year‑old woman with SpCC recurrence 4 years after an initial surgery to remove a well‑differentiated primary squamous cell carcinoma (SCC) of the tongue. The recurrent tumor was spherical and located deep within the tongue tissue, which differs from the typical manifestation of ulcerated masses of the mucosa. The majority of cases of recurrence involving SpCC are associated with radiotherapeutic treatment of the primary malignancy; however, the patient in the present study had not received postoperative radiotherapy for SCC. Furthermore, the recurrent tumor in the present case exhibited marked anaplasia and sarcomatoid features, and the absence of SCC elements upon biopsy rendered histological diagnosis difficult. In summary, the present findings suggest that immunohistochemical examination and identification of SCC components are essential for ensuring the accuracy of the histological diagnosis of recurrent SpCC following a primary epithelial malignancy.

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