Expression of Topoisomerase II‑α protein in salivary gland tumors

  • Authors:
    • Asaf Shvero
    • Ohad Hilly
    • Golan Bubis
    • Yaniv Hamzany
    • Rumelia Koren
    • Lea Rath‑Wolfson
  • View Affiliations

  • Published online on: October 20, 2017     https://doi.org/10.3892/mco.2017.1463
  • Pages:1064-1068
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Abstract

Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II‑α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, muco­epidermoid carcinoma, acinic cell carcinoma and carcinoma ex‑pleomorphic adenoma. A total of 59 cases of benign and malignant salivary gland tumors were included in the present study. Representative paraffin-embedded sections were immunostained for Topoisomerase II‑α (Topo II‑α). The expression level was semi‑quantified for each case and then correlated with the histological diagnosis using hematoxylin and eosin‑stained slides, grade of tumor and total survival. Significant differences were revealed between the expression level of Topo II‑α in pleomorphic adenoma and mucoepidermoid carcinoma (P<0.001), carcinoma ex‑pleomorphic adenoma (P<0.001), acinic cell carcinoma (P=0.005) and a group composed of all the malignant tumors (P<0.001). Cancer‑specific survival rates were insignificantly increased in tumors expressing low levels of Topo II‑α (P=0.464). Thus, the present study demonstrated different expression levels of Topo II‑α in benign and malignant salivary gland tumors. These differing expression levels may act as valuable biomarkers for the correct histological diagnosis. Further studies conducted on a larger scale may lead to even more conclusive results.

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December 2017
Volume 7 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Shvero, A., Hilly, O., Bubis, G., Hamzany, Y., Koren, R., & Rath‑Wolfson, L. (2017). Expression of Topoisomerase II‑α protein in salivary gland tumors. Molecular and Clinical Oncology, 7, 1064-1068. https://doi.org/10.3892/mco.2017.1463
MLA
Shvero, A., Hilly, O., Bubis, G., Hamzany, Y., Koren, R., Rath‑Wolfson, L."Expression of Topoisomerase II‑α protein in salivary gland tumors". Molecular and Clinical Oncology 7.6 (2017): 1064-1068.
Chicago
Shvero, A., Hilly, O., Bubis, G., Hamzany, Y., Koren, R., Rath‑Wolfson, L."Expression of Topoisomerase II‑α protein in salivary gland tumors". Molecular and Clinical Oncology 7, no. 6 (2017): 1064-1068. https://doi.org/10.3892/mco.2017.1463