C‑C motif chemokine receptors in gastric cancer (Review)

  • Authors:
    • Hyewon Ryu
    • Seung Woo Baek
    • Ji Young Moon
    • In‑Sook Jo
    • Nayoung Kim
    • Hyo Jin Lee
  • View Affiliations

  • Published online on: October 27, 2017     https://doi.org/10.3892/mco.2017.1470
  • Pages:3-8
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Abstract

Gastric cancer is the fifth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Despite recent advances in molecular and clinical research, patients with gastric cancer at an advanced stage have a dismal prognosis and poor survival rates, and systemic treatment relies predominantly on traditional cytotoxic chemotherapy. To improve patients' quality of life and survival, an improved understanding of the complex molecular mechanisms involved in gastric cancer progression and treatment resistance, and of its clinical application in the development of novel targeted therapies, is urgently required. Chemokines are a group of small chemotactic cytokines that interact with seven‑transmembrane G‑protein‑coupled receptors, and this interaction serves a crucial role in various physiological processes, including organ development and the host immune response, to recruit cells to specific sites in the body. There is also accumulating evidence that chemokines and chemokine receptors (CCRs) contribute to tumor development and progression, as well as metastasis. However, research regarding the functional roles of chemokines and their receptors in cancer is dynamic and context‑dependent, and much remains to be elucidated, although various aspects have been explored extensively. In gastric cancer, C‑C motif CCRs are involved in the biological behavior of tumor cells, including the processes of growth, invasion and survival, as well as the epithelial‑mesenchymal transition. In the present review, attention is given to the clinical relevance of C‑C motif CCRs in the development, progression, and metastasis of gastric cancer, particularly CCR7 and CCR5, which have been investigated extensively, as well as their potential therapeutic implications.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Ryu, H., Baek, S.W., Moon, J.Y., Jo, I., Kim, N., & Lee, H.J. (2018). C‑C motif chemokine receptors in gastric cancer (Review). Molecular and Clinical Oncology, 8, 3-8. https://doi.org/10.3892/mco.2017.1470
MLA
Ryu, H., Baek, S. W., Moon, J. Y., Jo, I., Kim, N., Lee, H. J."C‑C motif chemokine receptors in gastric cancer (Review)". Molecular and Clinical Oncology 8.1 (2018): 3-8.
Chicago
Ryu, H., Baek, S. W., Moon, J. Y., Jo, I., Kim, N., Lee, H. J."C‑C motif chemokine receptors in gastric cancer (Review)". Molecular and Clinical Oncology 8, no. 1 (2018): 3-8. https://doi.org/10.3892/mco.2017.1470