Open Access

Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast‑like giant cells: A case report

  • Authors:
    • Taro Sasaki
    • Hiroyuki Kawashima
    • Takashi Ariizumi
    • Tetsuro Yamagishi
    • Naoki Oike
    • Hajime Umezu
    • Shyoichi Inagawa
    • Tetsuo Hotta
    • Naoto Endo
    • Akira Ogose
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/mco.2017.1489
  • Pages:30-33
  • Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone leiomyosarcoma is a rare primary osseous malignant tumor with a high metastatic potential. Similar to other bone sarcomas, high histological grade and tumor stage are predictive of a poor outcome. We herein present our experience with treating a 64‑year‑old woman with bone leiomyosarcoma accompanied by multiple bone metastases. A biopsy revealed occasional osteoclast‑like giant cells. In addition to radiation therapy, the osteoclastogenesis inhibitor denosumab was administered but the patient did not undergo adjuvant chemotherapy or surgery. Good clinical and short‑term radiological responses to denosumab have been observed for 2 years. Therefore, denosumab may represent a viable treatment option without the need for adjuvant chemotherapy.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Sasaki, T., Kawashima, H., Ariizumi, T., Yamagishi, T., Oike, N., Umezu, H. ... Ogose, A. (2018). Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast‑like giant cells: A case report. Molecular and Clinical Oncology, 8, 30-33. https://doi.org/10.3892/mco.2017.1489
MLA
Sasaki, T., Kawashima, H., Ariizumi, T., Yamagishi, T., Oike, N., Umezu, H., Inagawa, S., Hotta, T., Endo, N., Ogose, A."Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 8.1 (2018): 30-33.
Chicago
Sasaki, T., Kawashima, H., Ariizumi, T., Yamagishi, T., Oike, N., Umezu, H., Inagawa, S., Hotta, T., Endo, N., Ogose, A."Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast‑like giant cells: A case report". Molecular and Clinical Oncology 8, no. 1 (2018): 30-33. https://doi.org/10.3892/mco.2017.1489