Open Access

Impact of the histological phenotype of extrahepatic bile duct carcinoma

  • Authors:
    • Kensuke Okano
    • Tadashi Yoshizawa
    • Takuya Miura
    • Keinosuke Ishido
    • Daisuke Kudo
    • Norihisa Kimura
    • Tai‑Ichi Wakiya
    • Yunyan Wu
    • Satoko Morohashi
    • Kenichi Hakamada
    • Hiroshi Kijima
  • View Affiliations

  • Published online on: October 27, 2017     https://doi.org/10.3892/mco.2017.1472
  • Pages:54-60
  • Copyright: © Okano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinicopathological features of extrahepatic cholangiocarcinoma, using 99 cases of surgically‑resected extrahepatic cholangiocarcinoma. All cases were divided into one of two histological phenotypes: Biliary‑type (BT; 56 cases, 56.6%) or metaplastic‑type (MT; 43 cases, 43.4%). The clinicopathological features were compared between these two phenotypes. BT tumors exhibited significantly poorer differentiation, more frequent lymph node metastasis (BT vs. MT, 42.9 vs. 30.2%; P=0.042), more severe venous invasion (v2‑3: BT vs. MT, 64.3 vs. 23.3%; P<0.001), and more severe perineural invasion (ne2‑3: BT vs. MT, 78.6 vs. 48.8%, P=0.002). Furthermore, the overall (P=0.015) and disease‑free (P=0.003) survival times were significantly decreased in patients with BT vs. MT tumors. In conclusion, extrahepatic cholangiocarcinoma with a BT phenotype has greater malignant potential, and may be an important predictive factor for poor prognosis.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9450
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Copy and paste a formatted citation
APA
Okano, K., Yoshizawa, T., Miura, T., Ishido, K., Kudo, D., Kimura, N. ... Kijima, H. (2018). Impact of the histological phenotype of extrahepatic bile duct carcinoma. Molecular and Clinical Oncology, 8, 54-60. https://doi.org/10.3892/mco.2017.1472
MLA
Okano, K., Yoshizawa, T., Miura, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Wu, Y., Morohashi, S., Hakamada, K., Kijima, H."Impact of the histological phenotype of extrahepatic bile duct carcinoma". Molecular and Clinical Oncology 8.1 (2018): 54-60.
Chicago
Okano, K., Yoshizawa, T., Miura, T., Ishido, K., Kudo, D., Kimura, N., Wakiya, T., Wu, Y., Morohashi, S., Hakamada, K., Kijima, H."Impact of the histological phenotype of extrahepatic bile duct carcinoma". Molecular and Clinical Oncology 8, no. 1 (2018): 54-60. https://doi.org/10.3892/mco.2017.1472