ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review)

  • Authors:
    • Ting Xiong
    • Gang Xu
    • Xue‑Long Huang
    • Kai‑Qiang Lu
    • Wei‑Quan Xie
    • Kai Yin
    • Jian Tu
  • View Affiliations

  • Published online on: November 15, 2017     https://doi.org/10.3892/mco.2017.1506
  • Pages:9-14
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Abstract

ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A‑I (apoA‑I), and is essential for the synthesis of high‑density lipoprotein. Mutations of the ABCA1 gene may induce Tangier disease and familial hypoalphalipoproteinemia; they may also lead to loss of cellular cholesterol homeostasis in prostate cancer, and increased intracellular cholesterol levels are frequently found in prostate cancer cells. Recent studies have demonstrated that ABCA1 may exert anticancer effects through cellular cholesterol efflux, which has been attracting increasing attention in association with prostate cancer. The aim of the present review was to focus on the current views on prostate cancer progression and the various functions of ABCA1, in order to provide new therapeutic targets for prostate cancer.

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January 2018
Volume 8 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Xiong, T., Xu, G., Huang, X., Lu, K., Xie, W., Yin, K., & Tu, J. (2018). ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review). Molecular and Clinical Oncology, 8, 9-14. https://doi.org/10.3892/mco.2017.1506
MLA
Xiong, T., Xu, G., Huang, X., Lu, K., Xie, W., Yin, K., Tu, J."ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review)". Molecular and Clinical Oncology 8.1 (2018): 9-14.
Chicago
Xiong, T., Xu, G., Huang, X., Lu, K., Xie, W., Yin, K., Tu, J."ATP‑binding cassette transporter A1: A promising therapy target for prostate cancer (Review)". Molecular and Clinical Oncology 8, no. 1 (2018): 9-14. https://doi.org/10.3892/mco.2017.1506