Efficacy and safety of DoceAqualip in a patient with locally advanced cervical cancer: A case report

  • Authors:
    • Rammohan Prasanna
    • Deepak Bunger
    • Mujtaba A. Khan
  • View Affiliations

  • Published online on: November 27, 2017     https://doi.org/10.3892/mco.2017.1519
  • Pages: 296-299
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Abstract

The standard of care for locally advanced cervical cancer has been the combination of a taxane with platinum based therapy. Conventional docetaxel is known to cause hypersensitivity reactions, fluid retention and other toxicities due to polysorbate-80 and ethanol. Corticosteroid premedication prior to docetaxel administration is required to prevent these toxicities, however, toxicities are still observed, sometimes fatal, despite premedication. DoceAqualip, a nanosomal docetaxel lipid suspension, developed with lipids generally regarded as safe (GRAS) by the US Food and Drug Administration, is devoid of polysorbate-80 and ethanol. DoceAqualip has been demonstrated to be effective and well‑tolerated in various cancer types. The authors' report a case of a patient with Stage IIIB cervical cancer who was treated with carboplatin and DoceAqualip (concurrent ChemoRT) and achieved complete response without any serious adverse events.

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February 2018
Volume 8 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Prasanna, R., Bunger, D., & Khan, M.A. (2018). Efficacy and safety of DoceAqualip in a patient with locally advanced cervical cancer: A case report. Molecular and Clinical Oncology, 8, 296-299. https://doi.org/10.3892/mco.2017.1519
MLA
Prasanna, R., Bunger, D., Khan, M. A."Efficacy and safety of DoceAqualip in a patient with locally advanced cervical cancer: A case report". Molecular and Clinical Oncology 8.2 (2018): 296-299.
Chicago
Prasanna, R., Bunger, D., Khan, M. A."Efficacy and safety of DoceAqualip in a patient with locally advanced cervical cancer: A case report". Molecular and Clinical Oncology 8, no. 2 (2018): 296-299. https://doi.org/10.3892/mco.2017.1519