A novel three‑way Philadelphia Variant t(9;22;17)(q34;q11.2;q12) in chronic myeloid leukemia: A case report
- Kathy Allen‑Proctor
- Elizabeth Ruckdeschel
- Rana Naous
Published online on: December 8, 2017
Chronic myeloid leukemia (CML) is a hematologic malignancy associated with increased circulating myeloid cells and platelets in the peripheral blood, with accompanying bone marrow hyperplasia. The Philadelphia chromosome, t(9;22)(q34;q11), is present in 95% of CML patients, resulting in constitutive tyrosine kinase activity; however, ~5% of CML patients possess a Philadelphia variant. A novel three‑way Philadelphia translocation variant, t(9;22;17)(q34;q11.2;q11.2), was identified in a 54‑year old man who presented with leukocytosis, anemia and thrombocytosis that was diagnosed with chronic myeloid leukemia, chronic phase. Cytogenetic analysis by G‑banding revealed the presence of a three‑way translocation involving the long arms of chromosomes 9, 22 and 17. Fluorescence is situ hybridization utilizing a dual‑color fusion probe confirmed the presence of the Bcr‑Abl fusion gene.