A novel three‑way Philadelphia Variant t(9;22;17)(q34;q11.2;q12) in chronic myeloid leukemia: A case report

  • Authors:
    • Kathy Allen‑Proctor
    • Elizabeth Ruckdeschel
    • Rana Naous
  • View Affiliations

  • Published online on: December 8, 2017     https://doi.org/10.3892/mco.2017.1529
  • Pages:300-301
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Abstract

Chronic myeloid leukemia (CML) is a hematologic malignancy associated with increased circulating myeloid cells and platelets in the peripheral blood, with accompanying bone marrow hyperplasia. The Philadelphia chromosome, t(9;22)(q34;q11), is present in 95% of CML patients, resulting in constitutive tyrosine kinase activity; however, ~5% of CML patients possess a Philadelphia variant. A novel three‑way Philadelphia translocation variant, t(9;22;17)(q34;q11.2;q11.2), was identified in a 54‑year old man who presented with leukocytosis, anemia and thrombocytosis that was diagnosed with chronic myeloid leukemia, chronic phase. Cytogenetic analysis by G‑banding revealed the presence of a three‑way translocation involving the long arms of chromosomes 9, 22 and 17. Fluorescence is situ hybridization utilizing a dual‑color fusion probe confirmed the presence of the Bcr‑Abl fusion gene.

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February 2018
Volume 8 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Allen‑Proctor, K., Ruckdeschel, E., & Naous, R. (2018). A novel three‑way Philadelphia Variant t(9;22;17)(q34;q11.2;q12) in chronic myeloid leukemia: A case report. Molecular and Clinical Oncology, 8, 300-301. https://doi.org/10.3892/mco.2017.1529
MLA
Allen‑Proctor, K., Ruckdeschel, E., Naous, R."A novel three‑way Philadelphia Variant t(9;22;17)(q34;q11.2;q12) in chronic myeloid leukemia: A case report". Molecular and Clinical Oncology 8.2 (2018): 300-301.
Chicago
Allen‑Proctor, K., Ruckdeschel, E., Naous, R."A novel three‑way Philadelphia Variant t(9;22;17)(q34;q11.2;q12) in chronic myeloid leukemia: A case report". Molecular and Clinical Oncology 8, no. 2 (2018): 300-301. https://doi.org/10.3892/mco.2017.1529