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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2008 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients

  • Authors:
    • Jung-Mi Park
    • Bon-Hee Gu
    • Eung-Ji Lee
    • Jae-Young Kim
    • Sung-Woo Choi
    • Kwang-Hyun Baek

  • View Affiliations / Copyright

    Affiliations: Graduate School of Life Science and Biotechnology, Cell and Gene Therapy Research Institute, Pochon CHA University, CHA General Hospital, Seoul 135-081, Korea
  • Pages: 93-97
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.93
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Abstract

Patients with polycystic ovarian syndrome (PCOS) are characterized by high levels of androgens, irregular or no menstrual cycle and increased hair growth. In addition, insulin resistance and glucose tolerance are caused in patients with PCOS. It was recently reported that PCOS in women is associated with a single nucleotide polymorphism (SNP) of genes, including the sorbin and SH3-domain-containing-1 (SORBS1) gene involved in insulin resistance and glucose uptake. SORBS1, which belongs to the sorbin homology (SoHo) family of proteins, becomes protein-protein interaction through three SH3 domains. In addition, SORBS1 is related to c-Cbl-associated protein (CAP) that has interacted with the downstream signaling components of glucose uptake. We therefore studied the association between the SNP of the SORBS1 gene and PCOS in a Korean population. SORBS1 raises glucose uptake and insulin resistance. The frequency of G allele was slightly higher in the patient group (n=233) than in the control group (n=105). A statistically significant relationship was found between the SNP in exon 7 of the SORBS1 gene and PCOS in a Korean population group.

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Gu B, Lee E, Kim J, Choi S and Baek K: A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients. Mol Med Rep 1: 93-97, 2008.
APA
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., & Baek, K. (2008). A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients. Molecular Medicine Reports, 1, 93-97. https://doi.org/10.3892/mmr.1.1.93
MLA
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., Baek, K."A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients". Molecular Medicine Reports 1.1 (2008): 93-97.
Chicago
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., Baek, K."A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients". Molecular Medicine Reports 1, no. 1 (2008): 93-97. https://doi.org/10.3892/mmr.1.1.93
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Gu B, Lee E, Kim J, Choi S and Baek K: A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients. Mol Med Rep 1: 93-97, 2008.
APA
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., & Baek, K. (2008). A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients. Molecular Medicine Reports, 1, 93-97. https://doi.org/10.3892/mmr.1.1.93
MLA
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., Baek, K."A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients". Molecular Medicine Reports 1.1 (2008): 93-97.
Chicago
Park, J., Gu, B., Lee, E., Kim, J., Choi, S., Baek, K."A single nucleotide polymorphism in exon 7 of sorbin and SH3-domain-containing-1 (SORBS1) in Korean PCOS patients". Molecular Medicine Reports 1, no. 1 (2008): 93-97. https://doi.org/10.3892/mmr.1.1.93
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