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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2008 Volume 1 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma

  • Authors:
    • Wenfeng Cao
    • Yanxue Liu
    • Hong Zhang
    • Shuhua Wang
    • Lihua Zhang
    • Lianyu Zhang
    • Baocun Sun

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China. caowenfeng@yahoo.com.cn
  • Pages: 363-368
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/mmr.1.3.363
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Abstract

Nasal-type NK/T cell lymphoma (NK/TCL) is an increasingly recognized disease entity of aggressive clinical behavior. The objective of this study was to investigate the correlation between the clinical features of NK/TCL and patient prognosis. Immunohistochemical detection of Epstein-Barr virus (EBV)-associated latent membrane protein (LMP)-1, Cyclin D1 and Bcl-2 protein expression, as well as TUNEL staining, were performed. Of the 58 cases studied, 47 (81%) displayed positive expression of LMP-1 protein, which was associated with the presence of B symptoms and patient prognosis. In addition, high expression of Cyclin D1 and Bcl-2 protein was observed to correlate with poor prognosis and decreased survival. More importantly, LMP-1 and Cyclin D1 appeared to be co-expressed. This, along with other parameters such as clinical stage at diagnosis and enlarged lymph nodes, could be used as an independent prognostic factor for clinical outcome, as the survival rate of NK/TCL patients was closely associated with LMP-1/Cyclin D1 co-expression, advanced clinical stage and lymph node infiltration.

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Copy and paste a formatted citation
Spandidos Publications style
Cao W, Liu Y, Zhang H, Wang S, Zhang L, Zhang L and Sun B: Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma. Mol Med Rep 1: 363-368, 2008.
APA
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., & Sun, B. (2008). Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma. Molecular Medicine Reports, 1, 363-368. https://doi.org/10.3892/mmr.1.3.363
MLA
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., Sun, B."Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma". Molecular Medicine Reports 1.3 (2008): 363-368.
Chicago
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., Sun, B."Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma". Molecular Medicine Reports 1, no. 3 (2008): 363-368. https://doi.org/10.3892/mmr.1.3.363
Copy and paste a formatted citation
x
Spandidos Publications style
Cao W, Liu Y, Zhang H, Wang S, Zhang L, Zhang L and Sun B: Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma. Mol Med Rep 1: 363-368, 2008.
APA
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., & Sun, B. (2008). Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma. Molecular Medicine Reports, 1, 363-368. https://doi.org/10.3892/mmr.1.3.363
MLA
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., Sun, B."Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma". Molecular Medicine Reports 1.3 (2008): 363-368.
Chicago
Cao, W., Liu, Y., Zhang, H., Wang, S., Zhang, L., Zhang, L., Sun, B."Expression of LMP-1 and Cyclin D1 protein is correlated with an unfavorable prognosis in nasal type NK/T cell lymphoma". Molecular Medicine Reports 1, no. 3 (2008): 363-368. https://doi.org/10.3892/mmr.1.3.363
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