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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2008 Volume 1 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2008 Volume 1 Issue 4

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Article

Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma

  • Authors:
    • Tadashi Hara
    • Hiroshi Kijima
    • Soichiro Yamamoto
    • Yosifumi Kise
    • Tomoko Hanashi
    • Takayuki Nishi
    • Osamu Chino
    • Hideo Shimada
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Kanagawa 259-1193, Japan
  • Pages: 473-477
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/mmr.1.4.473
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Abstract

p63, which has recently been identified as a member of the p53 gene family, plays many important roles in human tissue functions. We examined p63 expression patterns in esophageal Barrett's adenocarcinoma, including early-stage cancers, as well as its clinicopathological significance. Immunoreactivity for p63 was detected in 45.8% (11/24) of the adenocarcinomas; all cases were focally positive. p63 was detected not only in the in situ carcinomatous components or intramucosal carcinomas, but also in the invasive carcinomatous regions of the p63-positive cases. Immunohistochemical expression was correlated with clinicopathological features; i.e., lymph node metastasis, lymphatic invasion and venous invasion were found in 72.7% (p<0.01), 100% (p<0.05) and 90.9% (p<0.05) of the p63-positive cases, respectively, at a significantly high incidence compared with the p63-negative cases. We also analyzed the relationship between p63 and p53 expression. No diffuse expression of p63 was detected, although diffuse expression of p53 was detected in 50.0% (12/24) of the adenocarcinomas. The role of the p63 gene is thought to be different in esophageal Barrett's adenocarcinoma compared with esophageal squamous cell carcinoma. p63 immunoreactivity was most useful as a predictor of lymph node metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Hara T, Kijima H, Yamamoto S, Kise Y, Hanashi T, Nishi T, Chino O, Shimada H, Tanaka M, Inokuchi S, Inokuchi S, et al: Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma. Mol Med Rep 1: 473-477, 2008.
APA
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T. ... Makuuchi, H. (2008). Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma. Molecular Medicine Reports, 1, 473-477. https://doi.org/10.3892/mmr.1.4.473
MLA
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma". Molecular Medicine Reports 1.4 (2008): 473-477.
Chicago
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma". Molecular Medicine Reports 1, no. 4 (2008): 473-477. https://doi.org/10.3892/mmr.1.4.473
Copy and paste a formatted citation
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Spandidos Publications style
Hara T, Kijima H, Yamamoto S, Kise Y, Hanashi T, Nishi T, Chino O, Shimada H, Tanaka M, Inokuchi S, Inokuchi S, et al: Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma. Mol Med Rep 1: 473-477, 2008.
APA
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T. ... Makuuchi, H. (2008). Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma. Molecular Medicine Reports, 1, 473-477. https://doi.org/10.3892/mmr.1.4.473
MLA
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma". Molecular Medicine Reports 1.4 (2008): 473-477.
Chicago
Hara, T., Kijima, H., Yamamoto, S., Kise, Y., Hanashi, T., Nishi, T., Chino, O., Shimada, H., Tanaka, M., Inokuchi, S., Makuuchi, H."Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma". Molecular Medicine Reports 1, no. 4 (2008): 473-477. https://doi.org/10.3892/mmr.1.4.473
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