Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice

  • Authors:
    • Moreno Cocchietto
    • Laura Zorzin
    • Paolo Alberto Veronesi
    • Gianni Sava
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/mmr_00000039
  • Pages: 847-850
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Abstract

Human recombinant lysozymes (rHLZs), particularly hen egg-white lysozyme (HEL), are promising agents for the treatment of diseases such as cancer. However, in a similar but improved fashion to what has already been demonstrated using HEL, the PEGylation of an rHLZ leads to a new drug that appears to protect against spontaneous lung metastasis development in mice bearing mammary carcinoma (MCa). The oral administration of 25-100 mg/kg/day of rHLZ-PEG (HEL-equivalent dose) to CBA female mice, admixed with daily food for 14 consecutive days, significantly reduced the growth of the primary tumour by up to 30% and of lung metastasis weight by up to 95%, as compared to the untreated controls. An anti-metastatic effect significantly higher than that of uncoupled rHLZ was also confirmed in MCa-carrying animals immunosuppressed by cyclophosphamide or cyclosporine. This is of note if one takes into consideration the fact that virtually all chemotherapeutic regimens can cause immune system depression, with a consequent limitation of the dosage and effectiveness of anti-tumour treatments.

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November 2008
Volume 1 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Cocchietto, M., Zorzin, L., Veronesi, P.A., & Sava, G. (2008). Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice. Molecular Medicine Reports, 1, 847-850. https://doi.org/10.3892/mmr_00000039
MLA
Cocchietto, M., Zorzin, L., Veronesi, P. A., Sava, G."Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice". Molecular Medicine Reports 1.6 (2008): 847-850.
Chicago
Cocchietto, M., Zorzin, L., Veronesi, P. A., Sava, G."Oral poly(ethylene glycol)-conjugated human recombinant lysozyme control of lung metastases in mice". Molecular Medicine Reports 1, no. 6 (2008): 847-850. https://doi.org/10.3892/mmr_00000039