Open Access

Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells

  • Authors:
    • Lizhi Yi
    • Zhenbing Lv
    • Jianmei Wang
    • Xianfei Zhong
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/mmr.2017.7073
  • Pages: 3753-3760
  • Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Currently, with the increase of morbidity and mortality rate, gastric cancer (GC) is attracting increasing attention in China. Bcl‑2‑associated athanogene 4 (BAG4) has been identified as a tumor promoter in several tumors, but its role in GC remains unknown. The present study aimed to detect the expression of BAG4 and determine its function in the progression of GC. The results from reverse transcription‑quantitative polymerase chain reaction and western blotting revealed that BAG4 was markedly upregulated in highly metastatic cell lines (SGC7901 and MGC803), compared with the lower‑metastatic cell lines (AGS and BGC823). Through Cell Counting Kit‑8, cell cycle, apoptosis, Transwell and colony formation assays, BAG4 was demonstrated to promote the proliferation, migration and invasion of GC cells in vitro. Additionally, in vivo assays further certified that BAG4 can increase the proliferation and invasion of GC cells. In conclusion, these findings implicate BAG4 as a potential therapeutic target for GC.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yi L, Lv Z, Wang J and Zhong X: Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells. Mol Med Rep 16: 3753-3760, 2017
APA
Yi, L., Lv, Z., Wang, J., & Zhong, X. (2017). Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells. Molecular Medicine Reports, 16, 3753-3760. https://doi.org/10.3892/mmr.2017.7073
MLA
Yi, L., Lv, Z., Wang, J., Zhong, X."Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells". Molecular Medicine Reports 16.4 (2017): 3753-3760.
Chicago
Yi, L., Lv, Z., Wang, J., Zhong, X."Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells". Molecular Medicine Reports 16, no. 4 (2017): 3753-3760. https://doi.org/10.3892/mmr.2017.7073