Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma

  • Authors:
    • Luo‑Qin Fu
    • Ya‑Li Li
    • Ai‑Kun Fu
    • Yan‑Ping Wu
    • Yuan‑Yuan Wang
    • Sheng‑Lan Hu
    • Wei‑Fen Li
  • View Affiliations

  • Published online on: July 21, 2017     https://doi.org/10.3892/mmr.2017.7046
  • Pages: 4151-4158
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Abstract

Pidotimod is a synthetic dipeptide with biological and immuno‑modulatory properties. It has been widely used for treatment and prevention of recurrent respiratory infections. However, its impact on the regulation of allergic pulmonary inflammation is still not clear. In the current study, an ovalbumin (OVA)‑induced allergic asthma model was used to investigate the immune‑modulating effects of pidotimod on airway eosinophilia, mucus metaplasia and inflammatory factor expression compared with dexamethasone (positive control). The authors determined that treatment with pidotimod exacerbated pulmonary inflammation as demonstrated by significantly increased eosinophil infiltration, dramatically elevated immunoglobulin E production, and enhanced T helper 2 response. Moreover, treatment failed to attenuate mucus production in lung tissue, and did not reduce OVA‑induced high levels of FIZZ1 and Arg1 expression in asthmatic mice. In contrast, administration of dexamethasone was efficient in alleviating allergic airway inflammation in OVA‑induced asthmatic mice. These data indicated that pidotimod as an immunotherapeutic agent should be used cautiously and the effectiveness for controlling allergic asthma needs further evaluation and research.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Fu LQ, Li YL, Fu AK, Wu YP, Wang YY, Hu SL and Li WF: Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. Mol Med Rep 16: 4151-4158, 2017
APA
Fu, L., Li, Y., Fu, A., Wu, Y., Wang, Y., Hu, S., & Li, W. (2017). Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma. Molecular Medicine Reports, 16, 4151-4158. https://doi.org/10.3892/mmr.2017.7046
MLA
Fu, L., Li, Y., Fu, A., Wu, Y., Wang, Y., Hu, S., Li, W."Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma". Molecular Medicine Reports 16.4 (2017): 4151-4158.
Chicago
Fu, L., Li, Y., Fu, A., Wu, Y., Wang, Y., Hu, S., Li, W."Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma". Molecular Medicine Reports 16, no. 4 (2017): 4151-4158. https://doi.org/10.3892/mmr.2017.7046