microRNA‑372 inhibits proliferation and induces apoptosis in human breast cancer cells by directly targeting E2F1

Zhao,Ya‑Xin; Liu,Hua‑Cheng; Ying,Wei‑Yang; Wang,Cheng‑Yu; Yu,Yao‑Jun; Sun,Wei‑Jian; Liu,Jie‑Fan

doi:10.3892/mmr.2017.7591

microRNA‑372 inhibits proliferation and induces apoptosis in human breast cancer cells by directly targeting E2F1

Authors:
- Ya‑Xin Zhao
- Hua‑Cheng Liu
- Wei‑Yang Ying
- Cheng‑Yu Wang
- Yao‑Jun Yu
- Wei‑Jian Sun
- Jie‑Fan Liu
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Affiliations: Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of General Practice, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
Published online on: September 22, 2017 https://doi.org/10.3892/mmr.2017.7591
Pages: 8069-8075
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most prevalent cancer and the leading cause of cancer‑associated mortalities among women worldwide today. Accumulating evidence suggested that miR‑372 may serve important roles in the initiation and development of various human cancers. However, the role of miR‑372 in breast cancer remains unknown. The present study demonstrated that the expression level of miR‑372 in human breast cancer tissues and cell lines is significantly reduced compared with normal breast tissues cell lines. Furthermore, results of functional assays indicated that miR‑372 inhibits cell proliferation and induces apoptosis in the MCF‑7 human breast cancer cell line. E2F1 was identified as a direct functional target of miR‑372 in breast cancer. In conclusion, the findings revealed that miR‑372 may have the potential to act as a novel molecule for the diagnosis and therapy of patients with breast cancer.

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