Open Access

The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells

  • Authors:
    • Xue Li
    • Li Yang
    • Xin Sun
    • Junping Wu
    • Yu Li
    • Qiuyang Zhang
    • Yingchao Zhang
    • Kuan Li
    • Qi Wu
    • Huaiyong Chen
  • View Affiliations

  • Published online on: September 26, 2017     https://doi.org/10.3892/mmr.2017.7636
  • Pages:8155-8163
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The interaction between airway epithelial progenitor cells and their microenvironment is critical for maintaining lung homeostasis. This microenvironment includes fibroblast cells, which support the growth of airway progenitor cells. However, the mechanism of this support is not fully understood. In the present study, the authors observed that inhibition of transforming growth factor (TGF)‑β signal with SB431542 promotes the expression of hepatocyte growth factor (HGF) in fibroblast cells. The HGF receptor, c‑Met, is expressed on airway progenitor cells; HGF promotes the colony‑forming ability of airway progenitor cells. The deletion of Smad4 in airway progenitor cells increases the colony‑forming ability, suggesting that Smad4 plays a negative role in the regulating the proliferation of airway progenitor cells. These data demonstrated that the regulation of airway progenitor cells by TGF‑β depends on TGF‑βR1/2 on stromal cells, rather than on epithelial progenitor cells. These data suggested a role for the TGF‑β‑TGF‑βR1/2‑HGF‑Smad4 axis in airway epithelial homeostasis and sheds new light on the interaction between airway progenitor cells and their microenvironment.

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Journal Cover

December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

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Copy and paste a formatted citation
APA
Li, X., Yang, L., Sun, X., Wu, J., Li, Y., Zhang, Q. ... Chen, H. (2017). The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells. Molecular Medicine Reports, 16, 8155-8163. https://doi.org/10.3892/mmr.2017.7636
MLA
Li, X., Yang, L., Sun, X., Wu, J., Li, Y., Zhang, Q., Zhang, Y., Li, K., Wu, Q., Chen, H."The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells". Molecular Medicine Reports 16.6 (2017): 8155-8163.
Chicago
Li, X., Yang, L., Sun, X., Wu, J., Li, Y., Zhang, Q., Zhang, Y., Li, K., Wu, Q., Chen, H."The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells". Molecular Medicine Reports 16, no. 6 (2017): 8155-8163. https://doi.org/10.3892/mmr.2017.7636