Open Access

Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques

  • Authors:
    • Tiantian Liu
    • Hengfang Liu
    • Li Feng
    • Bo Xiao
  • View Affiliations

  • Published online on: October 3, 2017     https://doi.org/10.3892/mmr.2017.7694
  • Pages:8930-8936
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investigated the association between plaque vulnerable and inflammatory biomarkers using blood and plaque specimens. Carotid plaque specimens were obtained from 80 patients following stroke, 14 patients suffering from transient ischaemic attack and 17 asymptomatic patients that underwent carotid endarterectomy. To assess changes in plaque characteristics at histological levels, plaques were categorized by the time between the latest ischemic stroke and surgical intervention within 30, 30‑90, 90‑180 and over 180 days following stroke. Serum levels of inflammatory biomarkers interleukin (IL)‑6, IL‑10 and kinin B1 receptor (B1R) were measured by ELISA. Histological assessment of plaque was used to evaluate the plaque stability, progression and the inflammatory biomarker levels. Comparisons of histological characteristics demonstrated that plaques revealed an unstable phenotype following stroke within 30, 30‑90 days and then remodeled into more stable plaques following stroke at 90‑180 and over 180 days. By comparing the serum levels of inflammatory biomarkers, it was observed that IL‑6 and B1R levels tended to decline whereas IL‑10 levels increased in stroke patients from <30 days to over 180 days. Immunohistochemical analysis of IL‑6, IL‑10 and B1R demonstrated similar alterations in serum levels. Correlation analyses revealed that only B1R serum level was significantly correlated with histological level in patients with carotid atherosclerosis. The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis.

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December 2017
Volume 16 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
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APA
Liu, T., Liu, H., Feng, L., & Xiao, B. (2017). Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques. Molecular Medicine Reports, 16, 8930-8936. https://doi.org/10.3892/mmr.2017.7694
MLA
Liu, T., Liu, H., Feng, L., Xiao, B."Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques". Molecular Medicine Reports 16.6 (2017): 8930-8936.
Chicago
Liu, T., Liu, H., Feng, L., Xiao, B."Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques". Molecular Medicine Reports 16, no. 6 (2017): 8930-8936. https://doi.org/10.3892/mmr.2017.7694