Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis

  • Authors:
    • Jian‑Zhang Wang
    • Shou‑Xing Yang
    • Fangpeng Ye
    • Xuan‑Ping Xia
    • Xiao‑Xiao Shao
    • Sheng‑Long Xia
    • Bo Zheng
    • Chang‑Long Xu
  • View Affiliations

  • Published online on: December 15, 2017     https://doi.org/10.3892/mmr.2017.8283
  • Pages: 3797-3806
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Abstract

Rab11-family interacting proteins (Rab11‑FIPs) are associated with the progression of various tumors; however, their expression and clinical significance in colorectal cancer (CRC) remains largely undetermined. In this study, the clinical implications, functions and underlying mechanisms of Rab11‑FIP4 in CRC were investigated. Immunohistochemical analysis revealed that expression of Rab11‑FIP4 was significantly increased in human CRC tissues and correlated with poor prognosis of patients with CRC. Overexpression of Rab11‑FIP4 in the CRC cell line significantly promoted cell proliferation, migration and invasion in vitro and tumor metastasis in vivo. Furthermore, the results of a co‑immunoprecipitation assay and western blot analysis demonstrated that Rab11‑FIP4 interacted with Rab11 and insulin‑like growth factor 1 receptor, and increased the phosphorylation of extracellular signal‑regulated kinase 1/2 and AKT serine/threonine kinase. In addition, hypoxia contributed to the upregulation of Rab11‑FIP4 expression via hypoxia‑inducible factor‑1α activation of the Rab11‑FIP4 promoter. In conclusion, the results of the present study suggest that Rab11‑FIP4 may act as an oncogene in CRC, and may be a potential therapeutic target for the treatment of patients with CRC.
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March-2018
Volume 17 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang JZ, Yang SX, Ye F, Xia XP, Shao XX, Xia SL, Zheng B and Xu CL: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Mol Med Rep 17: 3797-3806, 2018
APA
Wang, J., Yang, S., Ye, F., Xia, X., Shao, X., Xia, S. ... Xu, C. (2018). Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Molecular Medicine Reports, 17, 3797-3806. https://doi.org/10.3892/mmr.2017.8283
MLA
Wang, J., Yang, S., Ye, F., Xia, X., Shao, X., Xia, S., Zheng, B., Xu, C."Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis". Molecular Medicine Reports 17.3 (2018): 3797-3806.
Chicago
Wang, J., Yang, S., Ye, F., Xia, X., Shao, X., Xia, S., Zheng, B., Xu, C."Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis". Molecular Medicine Reports 17, no. 3 (2018): 3797-3806. https://doi.org/10.3892/mmr.2017.8283