Open Access

MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism

  • Authors:
    • Hai‑Feng Zhang
    • Yi‑Cheng Wang
    • Yi‑Di Han
  • View Affiliations

  • Published online on: January 9, 2018     https://doi.org/10.3892/mmr.2018.8399
  • Pages: 4483-4489
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRs) have been proposed as minimally invasive prognostic markers for various types of cancer, including liver cancer, which is one of the most common cancers worldwide. In the present study, the expression of miR‑34a in human liver cancer tissues and cell lines was evaluated and the effects of miR‑34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. The results indicated that miR‑34a was downregulated in human liver cancer tissues. Overexpression of miR‑34a significantly inhibited liver cancer cell proliferation and clone formation. In terms of the underlying mechanism, miR‑34a was indicated to negatively regulate the expression of lactate dehydrogenase A (LDHA), which consequently inhibited LDHA‑dependent glucose uptake in the cancer cells, as well as cell proliferation and invasion. Collectively, these data suggest that miR‑34a functions as a negative regulator of glucose metabolism and may serve as a novel marker for liver cancer prognosis.
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March-2018
Volume 17 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang HF, Wang YC and Han YD: MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism. Mol Med Rep 17: 4483-4489, 2018
APA
Zhang, H., Wang, Y., & Han, Y. (2018). MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism. Molecular Medicine Reports, 17, 4483-4489. https://doi.org/10.3892/mmr.2018.8399
MLA
Zhang, H., Wang, Y., Han, Y."MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism". Molecular Medicine Reports 17.3 (2018): 4483-4489.
Chicago
Zhang, H., Wang, Y., Han, Y."MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism". Molecular Medicine Reports 17, no. 3 (2018): 4483-4489. https://doi.org/10.3892/mmr.2018.8399