Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma

Wu,Shuiqing; Jiang,Fen; Wu,Hongtao; Wang,Yinhuai; Xu,Ran; Cao,Jian; Lu,Qiong; Zhu,Xuan; Zhong,Zhaohui; Zhao,Xiaokun

doi:10.3892/mmr.2018.8409

Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma

Authors:
- Shuiqing Wu
- Fen Jiang
- Hongtao Wu
- Yinhuai Wang
- Ran Xu
- Jian Cao
- Qiong Lu
- Xuan Zhu
- Zhaohui Zhong
- Xiaokun Zhao
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Affiliations: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Gyeongsang 47392, Republic of Korea, Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: January 9, 2018 https://doi.org/10.3892/mmr.2018.8409
Pages: 4846-4852

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Abstract

The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis. Levels of HIF‑1α expression were detected by immunohistochemistry and the multivariate analysis was performed by proportional hazards regression. High levels of HIF‑1α expression were associated with a higher pathological stage and histological grade in patients with ccRCC (P<0.05). The median OS and PFS of patients with concomitant COPD were shorter compared with patients without COPD (P<0.05). The levels of serum hemoglobin, HIF‑1α expression and COPD diagnosis were all identified as independent prognostic variables for the OS and PFS of patients with ccRCC.

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