Open Access

miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts

  • Authors:
    • Bo Lu
    • Ian T. Christensen
    • Li‑Wei Ma
    • Xin‑Ling Wang
    • Ling‑Feng Jiang
    • Chun‑Xia Wang
    • Li Feng
    • Jin‑Song Zhang
    • Qi‑Chang Yan
  • View Affiliations

  • Published online on: January 25, 2018     https://doi.org/10.3892/mmr.2018.8492
  • Pages: 5021-5028
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNA-24 (miR-24) serves an important role in cell proliferation, migration and inflammation in various types of disease. In the present study, the biological function and molecular mechanism of miR‑24 was investigated in association with the progression of age‑associated cataracts. To the best of our knowledge the present study is the first to report that the expression of miR‑24 was significantly increased in human anterior lens capsules affected by age‑associated cataracts as well as lens epithelial cells (LECs) exposed to oxidative stress. Overexpression of miR‑24 induced p53 expression and p53 was verified as a direct target of miR‑24. Overexpression of miR‑24 enhanced LEC death by directly targeting p53. The present study revealed that oxidative stress induced the upregulation of miR‑24 and enhanced LEC death by directly targeting p53. These results suggest that the miR‑24‑p53 signaling pathway is involved in a novel mechanism of age‑associated cataractogenesis and miR‑24 may be a useful therapeutic target for age-associated cataracts.
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April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lu B, Christensen IT, Ma LW, Wang XL, Jiang LF, Wang CX, Feng L, Zhang JS and Yan QC: miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts. Mol Med Rep 17: 5021-5028, 2018
APA
Lu, B., Christensen, I.T., Ma, L., Wang, X., Jiang, L., Wang, C. ... Yan, Q. (2018). miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts. Molecular Medicine Reports, 17, 5021-5028. https://doi.org/10.3892/mmr.2018.8492
MLA
Lu, B., Christensen, I. T., Ma, L., Wang, X., Jiang, L., Wang, C., Feng, L., Zhang, J., Yan, Q."miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts". Molecular Medicine Reports 17.4 (2018): 5021-5028.
Chicago
Lu, B., Christensen, I. T., Ma, L., Wang, X., Jiang, L., Wang, C., Feng, L., Zhang, J., Yan, Q."miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts". Molecular Medicine Reports 17, no. 4 (2018): 5021-5028. https://doi.org/10.3892/mmr.2018.8492