search button

Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates

  • Authors:
    • Xuewen Su
    • Haifeng Yuan
    • Hongwei Cui
    • Hua Zhu
    • Xia Yun
    • Wenyan Tang
    • Junlong Chen
    • Zu Luan

  • View Affiliations

  • Published online on: January 29, 2018     https://doi.org/10.3892/mmr.2018.8511
  • Pages: 5552-5556
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Incidence of white matter injury (WMI), which is featured as softening of white matter tissues, has recently increased. Previous studies have demonstrated a close correlation between T helper cell 1 and T helper cell 2 (Th1/Th2) imbalance and nuclear factor‑κB (NF‑κB) with brain disease. Their role in premature WMI, however, remains to be illustrated. Serum samples were collected from 60 premature WMI neonates, plus another control group of 60 premature babies without WMI. Patients were further divided into mild, moderate and severe WMI groups. Reverse transcription quantitative polymerase chain reaction was used to test mRNA expression levels of Th1/Th2 cytokines, including interleukin 2 (IL)‑2, tumor necrosis factor‑α (TNF‑α), IL‑4, IL‑10 and nuclear factor (NF)‑κB, whilst their serum levels were measured by ELISA. Their correlation with disease occurrence and progression were further analysed, to illustrate the effect of Th1/Th2 balance and NF‑κB on pathology of premature WMI. Serum levels of IL‑4 and IL‑10 were significantly decreased in premature WMI babies, whilst IL‑2, TNF‑α and NF‑κB were upregulated (P<0.05 vs. control group). With aggravated disease, IL‑4 and IL‑10 expression was further decreased while IL‑2, TNF‑α and NF‑κB were increased (P<0.05 vs. mild WMI group). Th1 cytokines IL‑2 and TNF‑α and NF‑κB were negatively correlated with Th2 cytokines IL‑4 and IL‑10. Disease severity was positively correlated with IL‑2, TNF‑α and NF‑κB expression, and was negatively correlated with IL‑4 and IL‑10 (P<0.05). Th1/Th2 imbalance and NF‑κB upregulation were observed in WMI pathogenesis, with elevated secretion of Th1 cytokines and decreased Th2 cytokines, suggesting that Th1/Th2 imbalance and NF‑κB upregulation may be a potential indicator for the early diagnosis and treatment of WMI pathogenesis and progression.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 17 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Su X, Yuan H, Cui H, Zhu H, Yun X, Tang W, Chen J and Luan Z: Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates. Mol Med Rep 17: 5552-5556, 2018
APA
Su, X., Yuan, H., Cui, H., Zhu, H., Yun, X., Tang, W. ... Luan, Z. (2018). Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates. Molecular Medicine Reports, 17, 5552-5556. https://doi.org/10.3892/mmr.2018.8511
MLA
Su, X., Yuan, H., Cui, H., Zhu, H., Yun, X., Tang, W., Chen, J., Luan, Z."Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates". Molecular Medicine Reports 17.4 (2018): 5552-5556.
Chicago
Su, X., Yuan, H., Cui, H., Zhu, H., Yun, X., Tang, W., Chen, J., Luan, Z."Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates". Molecular Medicine Reports 17, no. 4 (2018): 5552-5556. https://doi.org/10.3892/mmr.2018.8511