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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model

  • Authors:
    • Guo-Qing Chen
    • Song Wang
    • Sheng-Yu Hu
  • View Affiliations / Copyright

    Affiliations: Department of Health Science, Wuhan Institute of Physical Education, Wuhan, Hubei 430079, P.R. China
  • Pages: 202-206
    |
    Published online on: September 22, 2011
       https://doi.org/10.3892/mmr.2011.596
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Abstract

Osteoporotic fractures commonly occur in the elderly. Current studies regarding cell proliferation and apoptosis during osteoporotic fracture healing are limited. In this study, we established an osteoporotic fracture healing model. Bone loss and callus formation were monitored with DXA, cell proliferation was examined using immunohistochemistry with BrdU monoclonal antibody and apoptotic cells were detected using the TUNEL method. Both cell proliferation and apoptosis occurred during the entire period of the study. BrdU immunostaining showed a decreasing tendency in the process of fracture healing. On days 20 and 30 post-fracture, the percentage of BrdU-positive cells in ovariectomized rats was significantly higher compared to sham-operated rats. TUNEL-positive chondrocytes reached a peak on day 20 post-fracture. There was no significant difference between the two groups. Our results indicate that osteoporosis markedly delays the fracture healing process, mostly due to increased chondrocyte proliferation without a change in chondrocyte apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Chen G, Wang S and Hu S: Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model. Mol Med Rep 5: 202-206, 2012.
APA
Chen, G., Wang, S., & Hu, S. (2012). Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model. Molecular Medicine Reports, 5, 202-206. https://doi.org/10.3892/mmr.2011.596
MLA
Chen, G., Wang, S., Hu, S."Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model". Molecular Medicine Reports 5.1 (2012): 202-206.
Chicago
Chen, G., Wang, S., Hu, S."Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model". Molecular Medicine Reports 5, no. 1 (2012): 202-206. https://doi.org/10.3892/mmr.2011.596
Copy and paste a formatted citation
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Spandidos Publications style
Chen G, Wang S and Hu S: Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model. Mol Med Rep 5: 202-206, 2012.
APA
Chen, G., Wang, S., & Hu, S. (2012). Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model. Molecular Medicine Reports, 5, 202-206. https://doi.org/10.3892/mmr.2011.596
MLA
Chen, G., Wang, S., Hu, S."Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model". Molecular Medicine Reports 5.1 (2012): 202-206.
Chicago
Chen, G., Wang, S., Hu, S."Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model". Molecular Medicine Reports 5, no. 1 (2012): 202-206. https://doi.org/10.3892/mmr.2011.596
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