Yessotoxin induces apoptosis in HL7702 human liver cells

  • Authors:
    • Min Pang
    • Pei Qu
    • Chun-Lei Gao
    • Zong-Ling  Wang
  • View Affiliations

  • Published online on: September 30, 2011     https://doi.org/10.3892/mmr.2011.606
  • Pages: 211-216
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Abstract

The marine toxin yessotoxin (YTX) is found in numerous aquatic environments and poses a potential threat to the shellfish industry and to public health. We analyzed the toxicity of YTX on HL7702 human liver cells using optical microscopy, Hoechst 33342 chromatin staining, DNA gel electrophoresis, rhodamine 123 staining and calcium-sensitive laser scanning confocal microscopy. The results demonstrated that YTX induced the usual hallmarks of apoptosis, including chromatin condensation, DNA laddering, activity of caspase-3 deregulation and loss of mitochondrial membrane potential. Furthermore, YTX caused cytosolic calcium levels to increase in HL7702 cells. YTX may cause liver damage through hepatocyte apoptosis.

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January 2012
Volume 5 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Pang M, Qu P, Gao C and Wang Z: Yessotoxin induces apoptosis in HL7702 human liver cells. Mol Med Rep 5: 211-216, 2012.
APA
Pang, M., Qu, P., Gao, C., & Wang, Z. (2012). Yessotoxin induces apoptosis in HL7702 human liver cells. Molecular Medicine Reports, 5, 211-216. https://doi.org/10.3892/mmr.2011.606
MLA
Pang, M., Qu, P., Gao, C., Wang, Z."Yessotoxin induces apoptosis in HL7702 human liver cells". Molecular Medicine Reports 5.1 (2012): 211-216.
Chicago
Pang, M., Qu, P., Gao, C., Wang, Z."Yessotoxin induces apoptosis in HL7702 human liver cells". Molecular Medicine Reports 5, no. 1 (2012): 211-216. https://doi.org/10.3892/mmr.2011.606