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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells

  • Authors:
    • Ai-Ping Lan
    • Liang-Can Xiao
    • Zhan-Li Yang
    • Chun-Tao Yang
    • Xiu-Yu Wang
    • Pei-Xi Chen
    • Mo-Fa Gu
    • Jian-Qiang Feng

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Radiotherapy, The Affiliated Cancer Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 250-255
    |
    Published online on: October 11, 2011
       https://doi.org/10.3892/mmr.2011.623
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Abstract

The present study investigated whether there is an interaction between reactive oxygen species (ROS) and p38 mitogen-activated protein kinase (MAPK) during chemical hypoxia-induced injury in PC12 cells. The results of the present study showed that cobalt chloride (CoCl2), a chemical hypoxia agent, markedly induced ROS generation and phosphorylation of p38MAPK, as well as neuronal injuries. N-acetylcysteine (NAC), a ROS scavenger, blocked CoCl2-induced phosphorylation of p38MAPK. In addition, SB203580, an inhibitor of p38MAPK attenuated not only CoCl2-induced activation of p38MAPK, but also ROS production. These results suggest that ROS and p38MAPK are capable of interacting positively during chemical hypoxia. Furthermore, NAC and SB203580 markedly prevented CoCl2-induced cytotoxicity, apoptosis and a loss of mitochondrial membrane potential. Taken together, our findings suggest that the positive interaction between CoCl2 induction of ROS and p38MAPK activation may play a significant role in CoCl2-induced neuronal injuries. We provide new insights into the mechanisms responsible for CoCl2-induced injuries in PC12 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Lan A, Xiao L, Yang Z, Yang C, Wang X, Chen P, Gu M and Feng J: Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells. Mol Med Rep 5: 250-255, 2012.
APA
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P. ... Feng, J. (2012). Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells. Molecular Medicine Reports, 5, 250-255. https://doi.org/10.3892/mmr.2011.623
MLA
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P., Gu, M., Feng, J."Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells". Molecular Medicine Reports 5.1 (2012): 250-255.
Chicago
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P., Gu, M., Feng, J."Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells". Molecular Medicine Reports 5, no. 1 (2012): 250-255. https://doi.org/10.3892/mmr.2011.623
Copy and paste a formatted citation
x
Spandidos Publications style
Lan A, Xiao L, Yang Z, Yang C, Wang X, Chen P, Gu M and Feng J: Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells. Mol Med Rep 5: 250-255, 2012.
APA
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P. ... Feng, J. (2012). Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells. Molecular Medicine Reports, 5, 250-255. https://doi.org/10.3892/mmr.2011.623
MLA
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P., Gu, M., Feng, J."Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells". Molecular Medicine Reports 5.1 (2012): 250-255.
Chicago
Lan, A., Xiao, L., Yang, Z., Yang, C., Wang, X., Chen, P., Gu, M., Feng, J."Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells". Molecular Medicine Reports 5, no. 1 (2012): 250-255. https://doi.org/10.3892/mmr.2011.623
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