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Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau

  • Authors:
    • Chunhua Jiang
    • Fuyu Liu
    • Yongjun Luo
    • Peng Li
    • Jian Chen
    • Gang Xu
    • Yujie Wang
    • Xiaoxu Li
    • Jian Huang
    • Yuqi Gao

  • View Affiliations

  • Published online on: October 14, 2011     https://doi.org/10.3892/mmr.2011.632
  • Pages: 287-293
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Chronic mountain sickness (CMS) is a condition in which the hematocrit is increased above the normal level in residents at high altitude. High altitude polycythemia (HAPC) is the most characteristic sign of CMS. However, the pathogenesis of HAPC is poorly understood. The present study aimed to investigate the gene expression profile of HAPC in Han Chinese migrating to the Qinghai-Tibetan Plateau and to identify the pathogenetic mechanisms. A total of 9 differentially expressed genes were identified in HAPC patients using microarrays: 5 were up-regulated and 4 were down-regulated. Functional analysis of the array data revealed that cell division cycle 42 (CDC42) and the human immune response may be key features underlying the mechanism and development of HAPC.

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January 2012
Volume 5 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Jiang C, Liu F, Luo Y, Li P, Chen J, Xu G, Wang Y, Li X, Huang J, Gao Y, Gao Y, et al: Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau. Mol Med Rep 5: 287-293, 2012
APA
Jiang, C., Liu, F., Luo, Y., Li, P., Chen, J., Xu, G. ... Gao, Y. (2012). Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau. Molecular Medicine Reports, 5, 287-293. https://doi.org/10.3892/mmr.2011.632
MLA
Jiang, C., Liu, F., Luo, Y., Li, P., Chen, J., Xu, G., Wang, Y., Li, X., Huang, J., Gao, Y."Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau". Molecular Medicine Reports 5.1 (2012): 287-293.
Chicago
Jiang, C., Liu, F., Luo, Y., Li, P., Chen, J., Xu, G., Wang, Y., Li, X., Huang, J., Gao, Y."Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau". Molecular Medicine Reports 5, no. 1 (2012): 287-293. https://doi.org/10.3892/mmr.2011.632